Nanozymes in bionanotechnology: from sensing to therapeutics and beyond

Wang, Xiaoyu; Hu, Yihui; Wei, Hui

doi:10.1039/c5qi00240k

Cited by 544 publications

(295 citation statements)

References 284 publications

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“…In 2007, Gao et al provided the first evidence that inert ferromagnetic nanoparticles have intrinsic peroxidase-like activity [5]. So far, it has been reported over 50 kinds of nanomaterials, which possess intrinsic activity similar to enzymes, such as magnetic nanoparticles, gold nanoparticles, platinum nanoparticles, cerium oxide nanoparticles and carbon nanomaterials [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Metal complexes, supramolecules and biomolecules have been extensively explored to mimic various intrinsic properties of natural enzymes [2]. Recently, nanoparticles (NPs) have attracted increasing attention because of their unique physicochemical properties, such as their comparable size to natural enzymes, high surface area to volume ratio, the presence of a large number of catalytically active sites on their surface and the availability of multifunctional reactive groups for modification and further functionalization [3,4]. In 2007, Gao et al provided the first evidence that inert ferromagnetic nanoparticles have intrinsic peroxidase-like activity [5].…”

Section: Introductionmentioning

confidence: 99%

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Low-Cost Nanocarbon-Based Peroxidases from Graphite and Carbon Fibers

et al. 2017

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Abstract:A low-cost and facile preparation of water-soluble carbon nanomaterials from commercial available graphite and polypropylene carbon fibers was achieved. N-doped graphene quantum dot was also prepared as a comparable agent. The resultant carbon nanomaterials were characterized by vital techniques such as transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), UV-vis absorption, Fourier transform infrared (FT-IR) and Raman spectra. The prepared carbon nanomaterials can make hydrogen peroxide degradation produce hydroxyl radicals, thus possess intrinsic peroxidase-like activity for colorimetric and UV-vis absorption detection of hydrogen peroxide. These carbon nanomaterials exhibit excellent sensitivity toward hydrogen peroxide with the limit of detection as low as 0.024 mM (by Carbon nanomaterials-1 from carbon fibers), 0.0042 mM (by Carbon nanomaterials-2 from graphite) and 0.014 mM (by Carbon nanomaterials-3 from nitrogen doped graphene oxide), respectively. The practical use of these carbon nanomaterials for phenolic compounds removal in aqueous solution is also demonstrated successfully. The extraordinary catalytic performance and low cost of these carbon nanomaterials make them a powerful tool for a wide range of potential applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-Cost Nanocarbon-Based Peroxidases from Graphite and Carbon Fibers

et al. 2017

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“…Nanozymes are nanomateirals with enzyme-like activities. [9][10][11][12] Noble metals, [13][14][15] carbons, [16][17][18] and metal oxides [19][20][21][22][23][24] have been demonstrated to mimic oxidase, peroxidase, catalase, and/or superoxide dismutase enzymes. Among these nanozymes, iron oxide is particularly interesting due to its unique magnetic property.…”

Section: Introductionmentioning

confidence: 99%

Iron oxide nanozyme catalyzed synthesis of fluorescent polydopamine for light-up Zn²⁺detection

2016

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Fluorescent polydopamine (FPD) is an interesting material with excellent biocompatibility.However, its preparation is currently a lengthy and potentially dangerous process. We herein employ magnetic iron oxide (Fe3O4) nanoparticles as a peroxidase-mimicking nanozyme to produce FPD under mild conditions. Different from previous protocols using multiple steps with up to 6% (~ 2 M) H2O2, this preparation takes place in a single step with just 5 mM H2O2 at room temperature. The oxidized product shows excitationwavelength-dependent emission peaks, similar to previous reports. The reaction kinetics, pH, temperature, and ionic strength are individually optimized. Among a diverse range of other nanomaterials tested, including Fe2O3, CeO2, CoO, Co3O4, NiO, TiO2, gold nanoparticles, and graphene oxide, Fe2O3 and graphene oxide also yielded relatively weak emission, while the rest of the materials failed to produce FPD. The Fe3O4 nanoparticles retained ~90% catalytic activity even after ten cycles of synthesis. Finally, Zn 2+ can enhance the fluorescence of FPD under 360 nm excitation but not under 480 nm excitation, leading to a sensitive light-up sensor with a detection limit of 60 nM Zn 2+ . Therefore, this work has demonstrated not only a novel use of nanozyme, but also an interesting application for FPD.3

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“…Iron containing compounds such as Fe coordinated with tetra-amidomacrocyclic, 44 and iron oxide NPs have peroxidase mimicking activity. [45][46][47][48] We suspect that the porous CP may also be an excellent peroxidase mimicking nanozyme. 49 We first compared the peroxidase activity of free Fe3O4, the Fe 3+ /AMP CP, and the Fe3O4@Fe 3+ /AMP using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) as the chromogenic in the presence of H2O2 ( Figure 4A).…”

Section: Encapsulation Of Nps the Above Successes In Trapping Varioumentioning

confidence: 99%

Magnetic Iron Oxide Nanoparticle Seeded Growth of Nucleotide Coordinated Polymers

Liang

Liu

Yuan

et al. 2016

ACS Appl. Mater. Interfaces

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Introducing functional molecules to the surface of magnetic iron oxide nanoparticles (NPs) is of critical importance. Most previously reported methods were focused on surface ligand attachment either by physisorption or covalent conjugation, resulting in limited ligand loading capacity. In this work, we report the seeded growth of a nucleotide coordinated polymer shell, which can be considered as a special form of adsorption by forming a complete shell. Among all the tested metal ions, Fe 3+ is the most efficient for this seeded growth. A diverse range of guest molecules including small organic dyes, proteins, DNA, and gold NPs can be encapsulated in the shell. All these molecules were loaded at a much higher capacity compared to that on the naked iron oxide NP core, confirming the advantage of the coordination polymer (CP) shell. In addition, the CP shell provides better guest protein stability compared to simple physisorption, while retaining guest activity as confirmed by the entrapped glucose oxidase assay. The use of this system as a peroxidase nanozyme and as a glucose biosensor was demonstrated, detecting glucose down to 1.4 µM with excellent stability. Together, this work describes a new way of functionalizing inorganic materials with a biocompatible shell.

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Nanozymes in bionanotechnology: from sensing to therapeutics and beyond

Abstract: Nanozymes are nanomaterials with enzyme-like characteristics, which have found broad applications in various areas including bionanotechnology and beyond.

Cited by 544 publications

References 284 publications

Low-Cost Nanocarbon-Based Peroxidases from Graphite and Carbon Fibers

Low-Cost Nanocarbon-Based Peroxidases from Graphite and Carbon Fibers

Iron oxide nanozyme catalyzed synthesis of fluorescent polydopamine for light-up Zn²⁺detection

Magnetic Iron Oxide Nanoparticle Seeded Growth of Nucleotide Coordinated Polymers

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Nanozymes in bionanotechnology: from sensing to therapeutics and beyond

Abstract: Nanozymes are nanomaterials with enzyme-like characteristics, which have found broad applications in various areas including bionanotechnology and beyond.

Cited by 544 publications

References 284 publications

Low-Cost Nanocarbon-Based Peroxidases from Graphite and Carbon Fibers

Low-Cost Nanocarbon-Based Peroxidases from Graphite and Carbon Fibers

Iron oxide nanozyme catalyzed synthesis of fluorescent polydopamine for light-up Zn2+detection

Magnetic Iron Oxide Nanoparticle Seeded Growth of Nucleotide Coordinated Polymers

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Product

Resources

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Iron oxide nanozyme catalyzed synthesis of fluorescent polydopamine for light-up Zn²⁺detection