2014
DOI: 10.17533/udea.vitae.17322
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Naphthoquinones: biological properties and synthesis of lawsone and derivates - a structured review

Abstract: Background: Naphthoquinones are natural pigments that are widely distributed in nature and have important biological activities. Lawsone (2-hydroxy-1,4-naphthoquinone) and its synthetic derivatives, and especially those containing nitrogen, have promising potential for the treatment of different diseases due to their antibacterial, antifungal, antiviral, antitumor and antiparasitic effects, and for pest control via their molluscicidal and insecticidal activities. Their pharmacological activities and mechanisms… Show more

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Cited by 83 publications
(17 citation statements)
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“…The starting materials, juglone (found in leaves, roots, husks, and barks of several species of walnut trees) and lawsone (isolated from the leaves and shoots of henna, Lawsonia inermis L.) have shown cytotoxicity against a wide range of human cancer cell lines [ 38 , 39 , 40 , 41 ]. Regarding the analogues investigated, cytotoxic properties for derivatives 4 , 6 and 10 , are described for the first time.…”
Section: Resultsmentioning
confidence: 99%
“…The starting materials, juglone (found in leaves, roots, husks, and barks of several species of walnut trees) and lawsone (isolated from the leaves and shoots of henna, Lawsonia inermis L.) have shown cytotoxicity against a wide range of human cancer cell lines [ 38 , 39 , 40 , 41 ]. Regarding the analogues investigated, cytotoxic properties for derivatives 4 , 6 and 10 , are described for the first time.…”
Section: Resultsmentioning
confidence: 99%
“…In this context, naphthoquinones, belonging to the quinone class, have a characteristic naphthalene ring, which gives them redox properties that can interfere with oxidative processes in biological systems [ 3 , 4 ]. They have stood out due to biological properties such as anti-inflammatory [ 5 , 6 ], antineoplastic [ [7] , [8] , [9] ], antimicrobial [ 3 , 10 ], antifungal [ 11 , 12 ] , antiviral [ 13 ] and antiparasitic [ 4 , 10 , [14] , [15] , [16] ] ones.…”
Section: Introductionmentioning
confidence: 99%
“…Naphthoquinones (NQs) are extensively distributed in nature and showed significant biological activities. Recent studies have also shed light on the neuroprotective effects, acetylcholinesterase inhibition, and Aβ aggregation inhibition performed by 1,4-NQ-derived compounds. Lawsone (2-hydroxy-1,4-napthoquinone) is the main natural dye from the leaves of Henna plants . AChEI activity of some synthetic lawsone derivatives and lawsone-like derivatives was reported. According to the in silico simulations, the 1,4-NQ system interacted with amino acid residues along the AChE active site gorge. , The para-quinone moiety primarily interacted with the amino acid residues at the CAS site, while the aromatic ring interacted with the amino acid residues in the PAS. , Therefore, lawsone was proposed to be a CAS ligand for the design of the hybrid molecule that act as dual binding site AChE inhibitors.…”
Section: Introductionmentioning
confidence: 99%