Naphthoyl benzhydrazine–decorated binuclear arene Ru(<scp>ii</scp>) complexes as anticancer agents targeting human breast cancer cells

Abirami, Arunachalam; Devan, Umapathy; Ramesh, Rengan; Antony Joseph Velanganni, Arockiam; Grzegorz Małecki, Jan

doi:10.1039/d3dt02552g

Dalton Trans.

2023

DOI: 10.1039/d3dt02552g

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Naphthoyl benzhydrazine–decorated binuclear arene Ru(ii) complexes as anticancer agents targeting human breast cancer cells

Arunachalam Abirami,

Umapathy Devan,

Rengan Ramesh

et al.

Abstract: Breast cancer is the most dangerous cancer in women and its fatality rate has increased over the decade ahead. To develop more potent and target-specific breast cancer drugs, six arene...

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Cited by 4 publications

References 67 publications

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Dinuclear arene ruthenium(II) arylthiourea complexes: Synthesis, structure, cancer cell growth inhibition and apoptosis induction studies

Balaji,

Subarkhan,

Balamurugan

et al. 2024

Applied Organom Chemis

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New half‐sandwich dinuclear arene ruthenium complexes of the general formula [(η6‐p‐cymene)Ru(k2‐S‐arylthiourea)Cl] (1–3) have been synthesized. The structural characterization of the ruthenium complexes has been established using analytical and various spectroscopic techniques. The bidentate coordination of the ligands and pseudo‐octahedral geometry around the ruthenium(II) ion are confirmed by the single‐crystal X‐ray diffraction technique. In vitro antiproliferative activity of the complexes has been studied by MTT (3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide) assay against lung (A549), breast (MCF‐7), cervical (HeLa), ovarian (A2780) cancer cells, and non‐cancerous NIH‐3T3 mouse embryonic fibroblast cells. The results show that all the complexes exhibit excellent cytotoxicity towards all the cancer cells, with a low IC50 concentration compared with cisplatin. Further, the mode of cancer cell death has been examined by AO–EB (acridine orange/ethidium bromide), and DAPI (4',6‐diamidino‐2‐phenylindole) staining studies demonstrate the apoptosis‐associated cell morphological changes. Furthermore, the quantitative differentiation of late apoptosis has been elucidated by flow cytometry employing dual staining of Annexin V‐FITC and propidium iodide, which involves the transfer of phosphatidylserine to the external leaflet of the cytoplasmic membrane.

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Dinuclear arene ruthenium(II) arylthiourea complexes: Synthesis, structure, cancer cell growth inhibition and apoptosis induction studies

Balaji,

Subarkhan,

Balamurugan

et al. 2024

Applied Organom Chemis

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Four new ruthenium(II) coordination compounds bearing coumarin derivatives as anticancer agents

Qin,

Zhou,

et al. 2024

Polyhedron

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Exploring the cytotoxicity of dinuclear Ru(ii) p-cymene complexes appended N,N′-bis(4-substituted benzoyl)hydrazines: insights into the mechanism of apoptotic cell death

Abirami,

Devan,

Ramesh

et al. 2024

Dalton Trans.

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Naphthoyl benzhydrazine–decorated binuclear arene Ru(ii) complexes as anticancer agents targeting human breast cancer cells

Abstract: Breast cancer is the most dangerous cancer in women and its fatality rate has increased over the decade ahead. To develop more potent and target-specific breast cancer drugs, six arene...

Cited by 4 publications

References 67 publications

Dinuclear arene ruthenium(II) arylthiourea complexes: Synthesis, structure, cancer cell growth inhibition and apoptosis induction studies

Dinuclear arene ruthenium(II) arylthiourea complexes: Synthesis, structure, cancer cell growth inhibition and apoptosis induction studies

Four new ruthenium(II) coordination compounds bearing coumarin derivatives as anticancer agents

Exploring the cytotoxicity of dinuclear Ru(ii) p-cymene complexes appended N,N′-bis(4-substituted benzoyl)hydrazines: insights into the mechanism of apoptotic cell death

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