Naphthyl-azine – aggregation induced emission, reversible acidochromism, cyanide sensing and its application in intracellular imaging

Abstract

Naphthylhydrazone derivative, 1-[(2-Hydroxy-4,6-dimethoxy-benzylidene)-hydrazonomethyl]-naphthalen-2-ol (H2L), an Aggregation Induced Emission (AIE) active probe emerges out as a promising solid-state emitter upon exercising restricted intramolecular rotation (RIR) in an ordered J-type self-assembly and...

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Aucore–Agshell Hybrid-Coating-Based Fiber Optical Sensor

“…Simultaneously, Au and Ag are known to be low-toxic and highly biocompatible metals, so this sensor is more user-friendly than optical sensors based on fluorescence switching. Sensors developed in recent years for CN – detection are mainly based on fluorescence on/off thanks to advantages such as high sensitivity, selectivity, and quick response. − However, the challenge of this method is choosing a luminous material and setting the procedures for monitoring changes in the fluorescence spectrum. Most organic fluorophores are toxic and are only soluble in organic solvents, thus causing limitations in the manufacturing process and practical applications .…”

“…The sensing process that relied on chemical reduction is quick and simple and required no additional cyanide identifiers or labels. Moreover, Au and Ag are known to be low-toxicity, highly biocompatible, and thus user-friendly compared to the sensors based on fluorescence quenching: The sensors developed in recent years for high sensitivity CN – detection that were mainly based on fluorescence on/off switching. − faced challenge of inevitable use of organic solvent for given organic fluorophores. This aspect caused limitation in easy manufacturing process and environment-friendly practical applications .…”

Aggregation-induced emission-active azines for chemosensing applications: a five-year update

“…5A and Table 2, entry 5]. 77 Azine 37 displayed typical AIE characteristics, having weak emission at 503 nm in ACN and the highest emission intensity at 80% water fractions with a bathochromic shift from 503 nm to 537 nm [Fig. 5B].…”

A triphenylamine scaffold for fluorogenic sensing of noxious cyanide via the ICT mechanism and its bioimaging application

“…Generally, the strategy behind the design of cyanide sensors is based upon hydrogen bonding, deprotonation, nanotechnology, supramolecular self-assembly, metal cyanide displacement and nucleophilic addition techniques. 25–31 However, the first few approaches lacked selectivity due to interference by protic solvents and competing ions, whereas the ion displacement technique requires a stabilized metal–ligand complex. On the contrary, a chemosensor based on a nucleophilic addition reaction, known as a chemodosimeter, possesses benefits such as high selectivity and sensitivity, and a rapid response time.…”