Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach

Abstract

Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as antimalarials and antileishmanial agents.

Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria

“…To counter drug resistance, several researchers are continuously striving to develop diverse classes of heterocyclic molecules, including quinolines, 1 thieno [2,3- d ]pyrimidine, 2 dipeptide-sulfonamides, 3 spirooxindoles, 4 pyrimidine, 5 and molecular hybrids. 6–8 The heterocyclic motif pyrazine exhibits diverse pharmacological properties and has been explored to develop antimycobacterial, antibacterial, antifungal, antidiabetic, diuretic, anticancer, antiviral, hypnotic, and analgesic agents. Some of the pyrazine derivatives are now clinically recognized drugs all over the world.…”