Naples prognostic score is an independent prognostic factor in patients with operable endometrial cancer: Results from a retrospective cohort study

Li, Qing; Cong, Rong; Wang, Yuting; Kong, Fanfei; Ma, Jian; Wu, Qi‐Jun; Ma, Xiaoxin

doi:10.1016/j.ygyno.2020.10.013

Cited by 40 publications

(54 citation statements)

References 37 publications

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“…The NLR and LMR were defined as the ratio of neutrophil count to lymphocyte count and lymphocyte count to monocyte count, respectively. The NPS was composed of the following four serum indicators (ALB, TC, NLR and LMR) according to the previous study (11)(12)(13)(14)(15)(16)(17)(18). ESCC has its own characteristics, and patients with ESCC are mostly malnourished, so the above hematological indicators may be different from other cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the results revealed that NPS was more sensitive than other conventional prognostic scores for OS prediction in patients with metastatic CRC according to the time-dependent ROC analysis. Since then, NPS has been further reported in patients with various cancers (13)(14)(15)(16)(17). We summarized published articles regarding the association between NPS and prognosis in cancers (Table 8).…”

Section: Discussionmentioning

confidence: 99%

“…According to the analyses with time-dependent receiver operating characteristic (ROC) curves, moreover, the study revealed that NPS was more sensitive than other conventional prognostic scores for OS prediction in patients with metastatic CRC. Since then, NPS has been further reported in patients with resected endometrial cancer, gastric cancer, early-stage lung cancer, osteosarcoma, and resected pancreatic cancer (13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

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Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

et al. 2021

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BackgroundNaples prognostic score (NPS) serves as a new prognostic index based on nutritional and inflammatory status in recent years. The aim of the current study was to explore the prognostic effect of NPS and to develop and validate a reliable nomogram based on NPS for individual cancer-specific survival (CSS) prediction in patients with resected ESCC without neoadjuvant therapy.MethodsThe clinical data for 287 (Jan. 2010 to Jun. 2012, Training sets) and 118 (Jan. 2015 to Dec 2015, Validation sets) consecutive resected ESCC cases were retrospectively analyzed. Two NPS models based on the different cut-off values of parameters were compared. Cut-off values in model 1 were derived from previous published studies, while cut-off values in model 2 were obtained in this study based on receiver operating characteristic (ROC) curves. The relationships between NPS and clinical characteristics and CSS were analyzed. The prediction model of nomogram was developed with independent prognostic factors in the training sets and was validated in the validation sets.ResultsThe 5-year CSS for NPS 0, 1 and 2 were 61.9%, 34.6% and 13.4% in model 1 and 75.0%, 42.4% and 13.0% in model 2, respectively (P<0.001). Subgroup analyses revealed that NPS was also significantly associated with CSS in both model 1 and model 2 in different TNM stages. Multivariate analyses revealed that NPS was an independent prognostic marker regarding CSS in patients with resected ESCC (P<0.001). A predictive nomogram based on NPS was established and validated. The C-indexes of the nomogram in the training sets and validation sets were 0.68 and 0.72 in model 1 and 0.69 and 0.73 in model 2, respectively. These results confirmed that NPS-based nomogram was a more accurate and effective tool for predicting CSS in patients with resected ESCC.ConclusionThe current study confirmed that NPS was still a useful independent prognostic score in patients with resected ESCC. The NPS-based nomogram was successfully developed and validated, which may contribute to individual CSS prediction for resected ESCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

et al. 2021

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“…We have recently demonstrated that NPS is a powerful predictor of long-term survival both in colorectal- and gastric-cancer patients [ 32 , 33 ]. Subsequently, many independent studies from different parts of the world, have shown that NPS is significantly correlated with oncological outcome in several human tumors including lung, endometrial, pancreatic, and gastro-esophageal cancers [ 28 , 50 , 51 , 52 , 53 ]. This is not surprising because NPS includes the neutrophil-to-lymphocyte and the lymphocyte-to-monocyte ratios which have been shown to be reliable surrogate indicators of the host inflammatory and immunological status [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Naples Prognostic Score Predicts Tumor Regression Grade in Resectable Gastric Cancer Treated with Preoperative Chemotherapy

Lieto¹,

Auricchio²,

Tirino

et al. 2021

Cancers

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Despite recent progresses, locally advanced gastric cancer remains a daunting challenge to embrace. Perioperative chemotherapy and D2-gastrectomy depict multimodal treatment of gastric cancer in Europe, shows better results than curative surgery alone in terms of downstaging, micrometastases elimination, and improved long-term survival. Unfortunately, preoperative chemotherapy is useless in about 50% of cases of non-responder patients, in which no effect is registered. Tumor regression grade (TRG) is directly related to chemotherapy effectiveness, but its understanding is achieved only after surgical operation; accordingly, preoperative chemotherapy is given indiscriminately. Conversely, Naples Prognostic Score (NPS), related to patient immune-nutritional status and easily obtained before taking any therapeutic decision, appeared an independent prognostic variable of TRG. NPS was calculated in 59 consecutive surgically treated gastric cancer patients after neoadjuvant FLOT4-based chemotherapy. 42.2% of positive responses were observed: all normal NPS and half mild/moderate NPS showed significant responses to chemotherapy with TRG 1–3; while only 20% of the worst NPS showed some related benefits. Evaluation of NPS in gastric cancer patients undergoing multimodal treatment may be useful both in selecting patients who will benefit from preoperative chemotherapy and for changing immune-nutritional conditions in order to improve patient’s reaction against the tumor.

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“…The Naples prognostic score (NPS), which is a new prognostic scoring system based on albumin, total cholesterol concentration, NLR, and LMR, comprehensively reflects the patient’s inflammation and nutritional status. Researchers have shown its predictive value in endometrial cancer, 17 colorectal cancer 18 and esophageal squamous cell carcinoma. 19 In addition, the predictive value of NPS is more accurate than that of other inflammatory-related and nutritional-related scoring systems.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer

Guo

Liu

et al. 2021

JIR

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Naples prognostic score is an independent prognostic factor in patients with operable endometrial cancer: Results from a retrospective cohort study

Cited by 40 publications

References 37 publications

Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma

Naples Prognostic Score Predicts Tumor Regression Grade in Resectable Gastric Cancer Treated with Preoperative Chemotherapy

Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer

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