Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism

Could routine vaccinations prevent dementia?

“…Prevention of MS through an EBV vaccine has been discussed, however a vaccine is not yet available. 54 There is also indirect evidence in the form of large epidemiological and observational studies showing a dose-dependent reduced risk of Alzheimer's in people using long-term anti-inflammatory drugs, 3,55,56 which is further supported in animal models 57 but has not yet been supported in human trials. 56 Given that vaccines were developed to ensure immunity from infections, a lack of current analogous findings does not necessarily call into question a causal link between vaccines and dementia: however, further studies linking the pathogenesis of neurodegenerative disorders to infections and to vaccines as a form of prevention would be of great value in validating the link between vaccines and dementia.…”

Differential effects of antiseizure medications on neurogenesis: Evidence from cells to animals

“…Both physiological and pathophysiological stimulus may affect the adult hippocampal neurogenesis process. On the other hand, alterations in brain neurogenesis may link to the pathogenesis of many neurologic, neurodegenerative, and neuropsychiatric disorders such as Alzheimer's disease [ 8 , 9 ], stress/anxiety and depression [ 10 ], schizophrenia [ 11 ], Parkinson's disease [ 12 ], stroke [ 13 ], epilepsy and age-related cognitive dysfunction [ 14 ].…”