Narbenbildung nach Hornhautvernetzung beim Keratokonus

Raiskup, Frederik; Kißner, A.; Hoyer, A.; Spörl, E.; Pillunat, Lutz E

doi:10.1007/s00347-009-2114-y

Cited by 18 publications

(10 citation statements)

References 14 publications

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“…36 The study designs of all included studies are described in Tables 1 and 2. The TE studies were all published in English, but five of the ER studies 56,59,[73][74][75] were published in German. Three [73][74][75] of these were excluded as they were redundant articles presenting data identical to an included English article.…”

Section: Resultsmentioning

confidence: 99%

“…The TE studies were all published in English, but five of the ER studies 56,59,[73][74][75] were published in German. Three [73][74][75] of these were excluded as they were redundant articles presenting data identical to an included English article. A further redundant article in English was excluded, 76 as was a large study that failed to present the sample size at follow-up.…”

Section: Resultsmentioning

confidence: 99%

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Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus

Shalchi

Wang

Nanavaty

2014

Eye

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This review aims to assess the efficacy and safety of epithelial removal (ER) and transepithelial (TE) corneal collagen crosslinking (CXL) for the treatment of keratoconus. We used MEDLINE to identify all ER and TE CXL studies on keratoconic eyes (n≥20, follow-up ≥12 months). Ex vivo and studies for non-keratoconus indications or in conjunction with other procedures were excluded. Data on uncorrected (UDVA) and corrected (CDVA) distance visual acuity, refractive cylinder, maximum keratometry (Kmax), and adverse events were collected at the latest follow-up and 1 year. Only one randomised controlled trial (RCT) qualified inclusion. Forty-four ER and five TE studies were included. For logMAR UDVA, CDVA, mean spherical equivalent, refractive cylinder and Kmax, at latest follow-up 81, 85, 93, 62, and 93% ER studies vs 66.7, 80, 75, 33, and 40% TE studies reported improvement, respectively. Whereas at 1 year, 90, 59, and 91% ER studies vs 80, 50, and 25% TE studies reported improvement, respectively. The majority of studies showed reduced pachymetry in both groups. Treatment failure, retreatment rates, and conversion to transplantation were reported to be up to 33, 8.6, and 6.25%, respectively, in ER studies only. Stromal oedema, haze, keratitis, and scarring were only reported in ER studies, whereas endothelial cell counts remained variable in both groups. Both ER and TE studies showed improvement in visual acuity, refractive cylinder but Kmax worsened in most TE studies. Adverse events were reported more with ER studies. This review calls for more high quality ER and TE studies with comparable parameters for further assessment of safety and efficacy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus

Shalchi

Wang

Nanavaty

2014

Eye

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“…Eine dauerhafte Narbenbildung muss von der oben beschriebenen transienten Trübungsbildung differenziert werden. Die Inzidenz von Narbenbildung nach Quervernetzung von fortgeschrittenen Keratokonushornhäuten wird mit bis zu 9% angegeben [37,38]. Diese Narben können frühpostoperativ oder nach Monaten auftreten [39].…”

Section: Haze Und Narbenunclassified

Komplikationen nach Hornhautquervernetzung

Taneri

Oehler

2014

Klin Monatsbl Augenheilkd

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Corneal cross-linking appears to have a high success rate and a low complication rate. Endothelial damage seems to be a far smaller problem than initially suspected. However, prospective studies with long-term follow-up are still lacking and it remains to be seen whether more cases of neoplasia following cross-linking will be reported. In our literature research we found no reports on re-treatments. Similarly, we found no study other than some case reports on keratoplasty after cross-linking. In view of rapidly changing treatment protocols further trials are warranted to monitor the benefits and complications of these modifications.

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“…Ob sich dies bei größeren Fallzahlen bestätigt bleibt abzuwarten. Raiskup et al konnten hohe K max-Werte (deutlich über 58 dpt) und niedrige Hornhautdicke als Risikofaktoren für eine Narbenbildung nach CXL identifizieren und empfehlen daher CXL vor allem für frühe Keratokonusstadien[35]. Sobald ausreichende Verlaufsdaten nach 2 Jahren zur Verfügung stehen, werden wir weitere potenziell prädikative Faktoren für eine effektive Crosslinking-Behandlung untersuchen.…”

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