Narcolepsy in Children: A Diagnostic and Management Approach

Babiker, Mohamed O E; Prasad, Manish

doi:10.1016/j.pediatrneurol.2015.02.020

Cited by 26 publications

(37 citation statements)

References 37 publications

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“…This Red Flag was formulated based on core literature consisting of the international diagnostic criteria [1], one evidence-based clinical summary [36], three reviews [3, 39, 40], one cohort study [24], one incidence cross-sectional study [41], one case report [42]In pediatric patients excessive daytime sleepiness may present with:• … sleep attacks , occurring in unusual and non-monotonous conditions, usually of brief duration, with a refreshing effect and with the recall of vivid dreams• .. change (acute or progressive) of sleep-wake circadian rhythm with the tendency to increase the total sleep hours per day, to resume the habitual napping that occurs beyond the age when a child typically grows out of the need for daily naps (i.e. after five to six years of age), to go to sleep earlier and to wake up later and with major difficulties in the morning awakening• … onset during daytime of hyperactivity, inattention, irritability and automatic behaviors .…”

Section: Resultsmentioning

confidence: 99%

Red Flags for early referral of people with symptoms suggestive of narcolepsy: a report from a national multidisciplinary panel

et al. 2018

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ObjectiveNarcolepsy is a lifelong disease, manifesting with excessive daytime sleepiness and cataplexy, arising between childhood and young adulthood. The diagnosis is typically made after a long delay that burdens the disease severity. The aim of the project, promoted by the “Associazione Italiana Narcolettici e Ipersonni” is to develop Red Flags to detect symptoms for early referral, targeting non-sleep medicine specialists, general practitioners, and pediatricians.Materials and methodsA multidisciplinary panel, including patients, public institutions, and representatives of national scientific societies of specialties possibly involved in the diagnostic process of suspected narcolepsy, was convened. The project was accomplished in three phases. Phase 1: Sleep experts shaped clinical pictures of narcolepsy in pediatric and adult patients. On the basis of these pictures, Red Flags were drafted. Phase 2: Representatives of the scientific societies and patients filled in a form to identify barriers to the diagnosis of narcolepsy. Phase 3: The panel produced suggestions for the implementation of Red Flags.ResultsRed Flags were produced representing three clinical pictures of narcolepsy in pediatric patients ((1) usual sleep symptoms, (2) unusual sleep symptoms, (3) endocrinological signs) and two in adult patients ((1) usual sleep symptoms, (2) unusual sleep symptoms). Inadequate knowledge of symptoms at onset by medical doctors turned out to be the main reported barrier to diagnosis.ConclusionsThis report will hopefully enhance knowledge and awareness of narcolepsy among non-specialists in sleep medicine in order to reduce the diagnostic delay that burdens patients in Italy. Similar initiatives could be promoted across Europe.Electronic supplementary materialThe online version of this article (10.1007/s10072-018-3666-x) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Red Flags for early referral of people with symptoms suggestive of narcolepsy: a report from a national multidisciplinary panel

et al. 2018

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“…5,9 Taking detailed medical history and being sensitive for variable presentations of narcolepsy are also important. 10 Lack of clinical awareness about the atypical presentations can result in misdiagnosis and inappropriate medication. 8 In this context, we see that our case was misdiagnosed with conversion disorder, and so inappropriate medication worsened her symptoms.…”

Section: Discussionmentioning

confidence: 99%

An under-recognized case of childhood narcolepsy with cataplexy

Güneş¹,

Camkurt²

2017

Anadolu Psikiyatri Derg

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“…In the same study, abuse and dependence were both rare as well, about 1 case for every 2,600 and 6,500 patients treated. 6,18,52,53 Antidepressants promote the action of norepinephrine and, to a lesser degree, serotonin, thereby suppressing REM sleep.…”

Section: For Cataplexymentioning

confidence: 99%