Naringenin (4,5,7-trihydroxyflavanone) as a potent neuroprotective agent: From chemistry to medicine

Amin, Insha; Majid, Sabiya; Farooq, Adil; Wani, Hilal Ahmad; Noor, Farida; Khan, Rehan; Shakeel, Sheeba; Bhat, Showkat Ahmad; Ahmad, Anas; Madkhali, Hassan; Ahmad, Majid; Rehman, Muneeb U.

doi:10.1016/b978-0-12-817905-5.00008-1

Cited by 20 publications

(8 citation statements)

References 112 publications

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“…Observed enzyme inhibitory properties of N. baytopii extracts might be explained by their chemical components. Some components such as apigenin, naringenin, luteolin, and chlorogenic acid have been reported as significant enzymes inhibitors [44][45][46][47][48][49][50][51][52][53][54], and thus, N. baytopii could be considered as a promising source of natural enzyme inhibitors. Interestingly, several researchers reported on the enzyme inhibition abilities of some Nepeta species.…”

Section: Resultsmentioning

confidence: 99%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

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Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.

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Section: Resultsmentioning

confidence: 99%

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Zengin

Mahomoodally

Jekő

et al. 2021

Plants

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“…[ 28 ] There are several studies available to reveal the strong anti-oxidant and anti-inflammatory properties of naringenin demonstrating its protective role against various neurological disorders and showing biological values in the conditions of epilepsy, depression, Parkinson's disease, dementia, and ischemic stroke. [ 29 ] Taken together, the present study might be proving helpful to extend the investigations on the molecular mechanisms and safety of the neuroprotective flavonoids studied to broaden the clinical applications in the management or mitigation of the complications of neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 90%

Anxiolytic effects of silibinin and naringenin on zebrafish model

Nachammai

Jeyabalan

Muthusamy

2021

Indian Journal of Pharmacology

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OBJECTIVE: Stress exacerbates the pathophysiology of major neurodegenerative disorders. In this study, the zebrafish ( Danio rerio ), the frequently used model for experimental studies of stress and other central nervous system disorders, was used to evaluate the anxiolytic potential of flavonoids, namely silibinin and naringenin on alleviating acute stress-induced anxiety. MATERIALS AND METHODS: A molecular docking study with Molegro Virtual Docker software was done to assess the binding potential of flavonoids on serotonin and dopamine receptors. To determine the bioactivity and investigate the toxicity of the flavonoids, silibinin, and naringenin, brine shrimp lethality assay, and an acute toxicity study was conducted according to Organization for Economic Co-operation and Development (OECD) Test Guideline 203. The effect of silibinin and naringenin was assessed using behavioral tasks such as the novel tank assay and the light-dark test on the zebrafish model of acute stress. RESULTS: Molecular docking studies showed a higher affinity of silibinin and naringenin for the serotonin and dopamine receptors. In comparison to the LC 50 value, 13.15 μg/ml of the reference standard potassium dichromate, silibinin, and naringenin yielded higher LC 50 values, 34.10 μg/ml and 91.33 μg/ml, respectively. The LC 50 value of silibinin and naringenin was observed to be >100 mg/l from the acute toxicity study on adult zebrafish. After transferring to a novel tank, silibinin and naringenin-treated zebrafish groups were found to explore the upper level of the tank, similar to standard drugs, and spent a long time in the upper level of the tank compared to the control group ( p < 0.01). Both silibinin and naringenin treatment group spent increased amounts of time in the tank's illuminated part in contrast to that of the dark side as evidenced by the number of zebrafish entering or remaining in the illuminated part of the tank through the light-dark test. Silibinin and naringenin treated groups were found to spend increased time in the light side significantly on the day 15 th of evaluation as compared to the control group ( p < 0.05 and p < 0.001, respectively). CONCLUSION: The flavonoids, silibinin, and naringenin were found to mitigate acute stress-induced anxiety, owing to their anxiolytic properties in the zebrafish model and may be explored as the potential therapeutic agents for treating anxiety.

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“… Naringenin Present in many citrus fruits such as Grapefruit ( Citrus paradisi ) , Sour orange ( Citrus aurantium ), tart cherries ( Prunus cerasus ), tomatoes ( Solanum lycopersicum ), and greek oregano ( Origanum vulgare L.). E. faecalis (256 μg/mL), VERF (512 μg/mL) Inhibition of β -Ketoacyl acyl carrier protein synthase (KAS) III (through in silico approach) [ 140 , 216 ] …”

Section: Antibacterial Agents Derived From the Mother Naturementioning

confidence: 99%

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

Jadimurthy

Mayegowda

Nayak

et al. 2022

Biotechnology Reports

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Naringenin (4,5,7-trihydroxyflavanone) as a potent neuroprotective agent: From chemistry to medicine

Cited by 20 publications

References 112 publications

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

Anxiolytic effects of silibinin and naringenin on zebrafish model

Escaping mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

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