Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death

Tseng, Yu‐Ting; Hsu, Hung-Te; Lee, Tzu-Ying; Chang, Wan-Hsuan; Lo, Yi-Ching

doi:10.1080/1028415x.2019.1594554

Cited by 26 publications

(17 citation statements)

References 43 publications

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“…Lu et al also reported that naringin and nobiletin could prevent ROS formation, and increased SOD and GSH activity in H 2 O 2 -induced PC12 cells [31]. Naringenin, an aglycone of naringin and narirutin, could decrease ROS production and increase GSH and SOD activities in methylglyoxal-treated NSC34 cells, indicating the potential benefits on the prevention of methylglyoxal-induced or diabetes/hyperglycemia-related neurotoxicity [32]. Zaidun et al reviewed antioxidants effects of naringenin, which were primarily attributed by reducing the ROS and improving the antioxidant capacities, such as SOD, CAT, and GSH in chronic diseases, for example, cardiovascular, neurodegenerative, diabetes, pulmonary, cancer, and nephropathy [33].…”

Section: Antioxidant Effects Of Citrus Herb Extracts On H 2 O 2 -Damamentioning

confidence: 93%

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Zhu

Zhou

et al. 2020

J of Separation Science

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The citrus herbs have proved their important medicinal and nutritional values as medicine–food dual‐purpose herbs, functional foods, or medical herbs in China. In this study, phytochemicals and antioxidant activity among ten typical citrus herbs (ethanol extracts) were investigated comprehensively. The major ingredients and their contents were analyzed by high‐resolution mass spectrometry, and the differences of typical fragment ions between flavanone‐7‐O‐rutinoside(s) and flavanone‐7‐O‐neohesperidoside(s) were discriminated properly in negative electrospray ionization mode. Total polyphenols, total flavonoids, 1,1‐diphenyl‐2‐picrylhydrazyl, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid), and ferric reducing antioxidant power tests were performed, which indicated their beneficial values and antioxidant effects. The medicine–food dual‐purpose herbs including Chenpi, Juluo, Daidaihua, Huajuhong, Xiangyuan, and Foshou exhibited antioxidant capacities significantly by decreasing intracellular reactive oxygen species intensity (P < 0.01), enhancing superoxide dismutase, catalase, and glutathione peroxidase activities (P < 0.01) in H2O2‐induced RIN‐m5F cells. Moreover, the functional foods Zhishi, Zhiqiao, and Qingpi showed moderate antioxidant bioactivity, while the medical herb Juhe showed weak antioxidant bioactivity, which were consistent with the multivariate analysis of their major flavonoids. The study provided a new sight for the chemical differentiation and practical application of citrus herbs as medicine–food dual‐purpose herbs, functional foods, or medical herbs.

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Section: Antioxidant Effects Of Citrus Herb Extracts On H 2 O 2 -Damamentioning

confidence: 93%

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Zhu

Zhou

et al. 2020

J of Separation Science

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“…Recently, many studies suggest that an essential role in the defense against oxidative stress, at cellular level, plays the Nrf2, nuclear factor erythroid 2-related factor 2, it activates under various stress conditions, such as exposure to reactive oxygen species or electrophilic stress. For example, genistein, naringenin, and epigallocatechin gallate can induce Nrf2 expression in human breast carcinoma, Caco-2, or endothelial cells and protect them from oxidant injury [ 3 , 4 , 17 , 35 , 36 ] and it exhibits anti-oxidant, anti-mutagenic, and anti-carcinogenic effects [ 37 , 38 ].…”

Section: Disscusionmentioning

confidence: 99%

Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids

et al. 2020

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Basil (Ocimum spp.) is a traditional herbal medicine abundant in antioxidants such as phenolic compounds. As part of a diet, this herb is proved to have some roles in decreasing the risk of cancer, and in the treatment of inflammation and neurodegenerative diseases. This study aims to explore the total phenolic and flavonoid content of two new basil hybrids growing in Romania, namely “Aromat de Buzau” (AB) and “Macedon” (MB). The antioxidant capacity of those two species was also analyzed by DPPH and cyclic voltammetry. Six different flavonoids, such as catechin (+), rutin, hyperoside, naringin, naringenin, and genistein, were separated, identified, and quantified by HPLC–DAD chromatography, for the first time, from romanian basil hybrids. The main flavonoid of the extracts was found to be naringin which is present in the highest amount (26.18 mg/kg) in “Aromat de Buzau” (O. basilicum) methanolic extract. These results suggest that dietary intake of these new hybrids can be a source of antioxidant compounds.

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“…Regarding the neurotoxic mechanisms, MG has been reported to interfere with signaling pathways involved in cellular metabolism, inflammation, oxidative stress, and apoptosis, resulting in the hippocampal neuronal toxicity [ 17 , 19 , 20 ]. In addition, MG possesses highly selective neurotoxicity in spinal motor neurons for the inefficiency of the glutathione (GSH) system [ 21 ], and it also contributes to limited neurite outgrowth and apoptotic death in cultured motor neuron-like cells [ 22 ]. Here, the protective effects of the chalcone derivative AN07 against MG-induced neuronal damage in human dopaminergic cells were examined.…”

Section: Introductionmentioning

confidence: 99%

“…In human dopaminergic SH-SY5Y cells, IGF-1 attenuated hyperglycemia-induced oxidative stress and neuronal injury via activation of the survival signaling cascade PI3K/Akt [ 27 ]. Previous studies suggested that drugs targeting IGF-1R-dependent signals possess the neuroprotective potential against diabetic-like neuronal apoptotic death and neurite damage induced by MG or high glucose [ 22 , 28 ]. Glucagon-like peptide 1 (GLP-1) is an endogenous insulinotropic peptide that is secreted by the intestinal endocrine cells with blood-glucose lowering effects by stimulating insulin secretion [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07

Chen

Gao

et al. 2020

Molecules

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Chalcones belong to a class of biologically active polyphenolic natural products. As a result of their simple chemical nature, they are easily synthesized and show a variety of promising biological activities. 2-Hydroxy-4′-methoxychalcone (AN07) is a synthetic chalcone derivate with potential anti-atherosclerosis effects. In this study, we demonstrated the novel antioxidant, anti-inflammatory, and neuroprotective effects of AN07. In RAW 264.7 macrophages, AN07 attenuated lipopolysaccharide (LPS)-induced elevations in reactive oxygen species (ROS) level and oxidative stress via down-regulating gp91phox expression and stimulating the antioxidant system of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) pathways, which were accompanied by increased glutathione (GSH) levels. Additionally, AN07 attenuated LPS-induced inflammatory factors, including NO, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and phosphorylated inhibitor of nuclear factor kappa B-alpha (p-IκBα) in RAW 264.7 macrophages. However, the effects of AN07 on promoting nuclear Nrf2 levels and decreasing COX-2 expressions were significantly abrogated by the peroxisome proliferator-activated receptor-γ (PPARγ) antagonist GW9662. In human dopaminergic SH-SY5Y cells treated with or without methylglyoxal (MG), a toxic endogenous by-product of glycolysis, AN07 up-regulated neurotrophic signals including insulin-like growth factor 1 receptor (IGF-1R), p-Akt, p-GSK3β, glucagon-like peptide 1 receptor (GLP-1R), and brain-derived neurotrophic factor (BDNF). AN07 attenuated MG-induced apoptosis by up-regulating the B-cell lymphoma 2 (Bcl-2) protein and down-regulating the cytosolic expression of cytochrome c. AN07 also attenuated MG-induced neurite damage via down-regulating the Rho-associated protein kinase 2 (ROCK2)/phosphorylated LIM kinase 1 (p-LIMK1) pathway. Moreover, AN07 ameliorated the MG-induced down-regulation of neuroprotective Parkinsonism-associated proteins parkin, pink1, and DJ-1. These findings suggest that AN07 possesses the potentials to be an anti-inflammatory, antioxidant, and neuroprotective agent

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Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death

Cited by 26 publications

References 43 publications

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Comparative investigation of phytochemicals among ten citrus herbs by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry and evaluation of their antioxidant properties

Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids

The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07

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