Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt’s lymphoma cells

Kim, Jeong Hwa; Lee, Jae Kwon

doi:10.1007/s12272-015-0624-5

Cited by 30 publications

(12 citation statements)

References 28 publications

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“…In contrast, the thermally processed naringenin presented the best activity at the highest tested concentrations (21.6 μg/ml). Our findings are in accordance with a recent study conducted by Kim and Lee (2015). Macrophages perform a central role in innate and adaptive immunity through the lysosomal pathway.…”

Section: Discussionsupporting

confidence: 94%

Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

Maâtouk

Elgueder

Mustapha

et al. 2016

Cell Stress and Chaperones

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Naringenin is one of the most popular flavonoids derived from citrus. It has been reported to be an effective antiinflammatory compound. Citrus fruit may be used raw, cooked, stewed, or boiled. The present study was conducted to investigate the effect of thermal processes on naringenin in its immunomodulatory and cellular antioxidant activities. The effects of flavonoids on B and T cell proliferation were assessed on splenocytes stimulated or not with mitogens. However, their effects on cytotoxic T lymphocyte (CTL) and natural killer (NK) activities were assessed in splenocytes co-incubated with target cells. The amount of nitric oxide production and the lysosomal enzyme activity were evaluated in vitro on mouse peritoneal macrophages. Cellular antioxidant activity in splenocytes and macrophages was determined by measuring the fluorescence of the dichlorofluorescin (DCF). Our findings revealed that naringenin induces B cell proliferation and enhances NK activity. The highest concentration of native naringenin exhibits a significant proliferation of T cells, induces CTL activity, and inhibits cellular oxidation in macrophages. Conversely, it was observed that when heatprocessed, naringenin improves the cellular antioxidant activity in splenocytes, increases the cytotoxic activity of NK cells, and suppresses the cytotoxicity of T cells. However, heat treatment maintains the anti-inflammatory potency of naringenin.

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Section: Discussionsupporting

confidence: 94%

Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

Maâtouk

Elgueder

Mustapha

et al. 2016

Cell Stress and Chaperones

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“…Naringenin is a naturally occurring flavanone known to have anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative, hepatoprotective and antiatherogenic activities [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach

et al. 2020

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As a Turkish traditional medicinal plant, aerial parts of Lotus corniculatus L. subsp. corniculatus (Fabaceae) are used as a painkiller, antihemoroidal, diuretic and sedative. In this study, the antidepressant potential of the plant has been attempted to clarify. Extracts with water, n-Hexane, ethyl acetate, and methanol were prepared respectively from the aerial parts. Antidepressant activity of the extracts were researched by using three different in vivo test models namely a tail suspension test, antagonism of tetrabenazine-induced hypothermia, ptosis, and suppression of locomotor activity and forced swimming test on male BALB/c mice and in vitro monoamine oxidase (MAO)-A and B inhibition assays. The results were evaluated through comparing with control and reference groups, and then active compounds of the active extract have been determined. Bioassay-guided fractionation of active fraction led to the isolation of three compounds and structures of the compounds were elucidated by spectroscopic methods. The data of this study demonstrate that the MeOH extract of the aerial parts of the plant showed remarkable in vivo antidepressant effect and the isolated compounds medicarpin-3-O-glucoside, gossypetin-3-O-glucoside and naringenin-7-O-glucoside (prunin) from the active sub-fractions could be responsible for the activity. Further mechanistic and toxicity studies are planned to develop new antidepressant-acting drugs.

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“…It also has the ability to chelate iron (including Fe 3+ ) and copper ions and its dependence of structure and pH . Besides, NRG possesses antioxidant properties, preventing the depletion of SOD, CAT, GPx, and GSH . Recent studies indicate that NRG possesses several beneficial effects on tissues, and heavy metals intoxication and these results can be explained by its antioxidant effects.…”

Section: Discussionmentioning

confidence: 99%

The effect of naringenin on the role of nuclear factor (erythroid‐derived 2)‐like2 (Nrf2) and haem oxygenase 1 (HO‐1) in reducing the risk of oxidative stress‐related radiotoxicity in the spleen of rats

Abdel‐Magied

Shedid

2019

Environmental Toxicology

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The present study was to evaluate the radiomitigative effect of naringenin (NRG) on the modulation of ionizing radiation (IR)‐induced spleen injury. Rats were exposed to 12 Gy (3Gy/two times/week). NRG (50mg/Kg), was orally given one hour after the first radiation dose, and daily continued during the irradiation period. Rats were sacrificed 1 day after the last dose of radiation. NRG showed a significant decrease of malondialdehyde, hydrogen peroxide with a significant elevation of superoxide dismutase, catalase and glutathione peroxidase activities and glutathione content. Moreover, NRG confirmed the intracellular defense mechanisms through activation of nuclear factor (erythroid‐derived 2)‐like2 (Nrf2) and haem oxygenase‐1 (HO‐1) levels and their protein expression. In addition, NRG deactivated the nuclear factor‐κB (NF‐κB) and reduced the pro‐inflammatory cytokines. Further, NRG showed positive modulation in the haematological values (WBCs, RBCs, Hb, Hct% and PLt). In conclusion, these results suggested that NRG reversed the IR‐induced redox‐imbalance in the rat spleen.

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Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt’s lymphoma cells

Cited by 30 publications

References 28 publications

Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity

Antidepressant Potential of Lotus corniculatus L. subsp. corniculatus: An Ethnobotany Based Approach

The effect of naringenin on the role of nuclear factor (erythroid‐derived 2)‐like2 (Nrf2) and haem oxygenase 1 (HO‐1) in reducing the risk of oxidative stress‐related radiotoxicity in the spleen of rats

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