2024
DOI: 10.1002/jbt.23717
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Naringenin mitigates aluminum toxicity‐induced learning memory impairments and neurodegeneration through amelioration of oxidative stress

Ravina Rai,
Deepali Jat,
Siddhartha Kumar Mishra

Abstract: Aluminum chloride (AlCl3) is a potent neurotoxic substance known to cause memory impairment and oxidative stress‐dependent neurodegeneration. Naringenin (NAR) is a dietary flavonoid with potent antioxidant and anti‐inflammatory properties which was implemented against AlCl3‐induced neurotoxicity to ascertain its neuroprotective efficacy. Experimental neurotoxicity in mice was induced by exposure of AlCl3 (10 mg/kg, p.o.) followed by treatment with NAR (10 mg/kg, p.o.) for a total of 63 days. Assessed the morph… Show more

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