Naringin attenuates cisplatin‐ and aminoglycoside‐induced hair cell injury in the zebrafish lateral line via multiple pathways

Abstract

Ototoxicity refers to the pathological and functional impairments of auditory nervous system caused by the application of some therapeutic drugs. Although drug-induced hearing loss is not fatal, it will seriously damage the social and health-related quality of patients, with significant implications for careers, education and society. In children, even minor hearing loss can impede speech, language, cognition and social development, which can lead to poor academic performance and psychosocial functioning. 1-5 Worldwide, around 30 thousand children suffer from cytotoxic agents every year. Currently, there are more than 600 drugs having ototoxic properties, such as aminoglycoside antibiotics, platinum-based chemotherapy drugs, cyclic diuretics, macrolides and

Cisplatin exposure acutely disrupts mitochondrial bioenergetics in the zebrafish lateral-line organ

“…The relationship between cisplatin and oxidative stress has been well established ( Gentilin et al, 2019 ; Kros and Steyger, 2019 ; Sheth et al, 2017 ), and prior studies demonstrate that mitochondria play a key role in cisplatin-induced oxidative stress in cancer and non-cancer cell lines ( Marullo et al, 2013 ) as well as hair cells ( Li et al, 2021 ; Lu et al, 2022 ). Here, we build on this literature and demonstrate that oxidative stress occurs shortly after cisplatin exposure.…”

Naringin Improves Osteoblast Mineralization and Bone Healing and Strength through Regulating Estrogen Receptor Alpha-Dependent Alkaline Phosphatase Gene Expression

“…Moreover, naringin may possess potential roles in treating various diseases, such as osteoporosis and degenerative disorders of different tissues, including neurons, because this phytochemical is able to stimulate MSC proliferation and lineage differentiation . In contrast, naringin had opposite bioactivity in a variety of cancer cells of inhibiting cell proliferation or even killing drug-sensitive or -resistant tumor cells via multiple signal-transducing mechanisms. , For example, naringin suppressed osteosarcoma cell proliferation and metastasis . Results of a MTT assay also demonstrated that naringin increased mitochondrial succinate dehydrogenase activity.…”

“…46 In contrast, naringin had opposite bioactivity in a variety of cancer cells of inhibiting cell proliferation or even killing drug-sensitive or -resistant tumor cells via multiple signal-transducing mechanisms. 47,48 For example, naringin suppressed osteosarcoma cell proliferation and metastasis. 49 Results of a MTT assay also demonstrated that naringin increased mitochondrial succinate dehydrogenase activity.…”

Hair cell toxicology: With the help of a little fish

“…Therefore, the need for effective otoprotectants exists, and the hair cells of the zebrafish larvae are a useful model to speed up that goal ( Ton and Parng, 2005 ). Some of the mentioned antioxidant compounds have been positively tested against ototoxins in zebrafish larvae, like glutathione, allopurinol, N-acetylcysteine, D-methionine ( Ton and Parng, 2005 ), L-Serine ( Monroe et al, 2021 ), a curcuminoid ( Monroe et al, 2018 ), flavonoids, like naringin ( Li et al, 2021 ) or quercetin ( Lee et al, 2015 ; Hirose et al, 2016 ), a small peptide ( Xiao et al, 2018 ), or ferrostatin ( Hu et al, 2020 ).…”