Naringin dietary supplementation at 0.15% rates does not provide protection against sub-clinical acidosis and does not affect the responses of fattening lambs to road transportation

Abstract

Forty Assaf fattening lambs (initial age 13 to 15 weeks) offered a diet of barley straw and a commercial concentrate were used to assess the effect of naringin (a type of citrus flavonoid with proven antioxidant, antimicrobial and anti-inflammatory properties in monogastric animals) at a dose of 1.5 g/kg per dry matteron plasma lipid peroxidation thiobarbituric acid reactive substances (TBARS), immune response, ruminal bacterial community and protection provided by the ruminal wall against subclinical acidosis. After 49 days of the experimental diets, lambs were subjected to a 4-h transportation stress period. As expected, TBARS values were significantly increased in all the lambs just after the transportation period, but no effect of naringin was observed. Although naringin lowered red blood cell count, neither the total white blood cells counts nor the production of IFN-g were affected by naringin. No anti-inflammation activity preventing rumenitis was detected, but a clear effect on ruminal bacterial community was observed in lambs consuming naringin. Further experiments, using different doses of naringin might show health benefits of naringin supplementation in lambs, but a clear beneficial effect on health was not readily apparent in this study.

The liver antioxidant status of fattening lambs is improved by naringin dietary supplementation at 0.15% rates but not meat quality

“…In addition, Gnanamani et al (2008) suggested a chelating effect of naringenin (the aglycone fraction of naringin) on the ferrous ion needed to form the central core of both haemoglobin and myoglobin. Both reports are in agreement with the lower red blood cell counts detected in the NARINGIN group when compared with the CONTROL group (Ló pez-Campos et al, 2010). Regarding the effects on meat colour, only numerical TBARS 5 thiobarbituric acid-reactive substances procedure; MDA5malondialde-hyde; 7a-HC 5 7a-hydroxycholesterol; 7b-HC 5 7b-hydroxycholesterol; a-CE 5 5,6a-epoxycholesterol; b-CE 5 5,6b-epoxycholesterol; CT 5 cholestanetriol; 25-HC 5 25-hydroxycholesterol; 7-KC 5 7-ketocholesterol.…”

Effect of Chitosan and Naringin on Enteric Methane Emissions in Crossbred Heifers Fed Tropical Grass

“…Previous reports on flavonoids have shown that degradation products including NA may be metabolized to volatile fatty acids and thus modify microbial diversity in the rumen, enhancing the molar proportion of propionate while decreasing the acetate:propionate ratio [19,61]. Balcells et al [62] fed a concentrate, barley straw, and supplemented Fleckvieh heifers with Bioflavex (containing NA) (0.3 g/kg DM) and recorded an increase in the molar proportion of propionate.…”

“…Naringin is responsible for the distinctive sour flavor and bitter taste of grapefruits and other citrus fruits. It possesses a wide range of biological effects such as antioxidant, anti-inflammatory (in vitro and in vivo), immune response, antiapoptotic, hepatoprotective, and cardioprotective effects, along with improving gut health and having a beneficial effect in certain metabolic diseases [19,20]. Flavonoids have antimicrobial properties that may participate in the reduction of methanogenic archaea, replace chemical compounds and, at the same time, improve animal health, feed efficiency, and productivity [21,22].…”

Ruminal Acidosis Part II: Diagnosis, Prevention and Treatment

“…β-sitosterol (BSS), one phytosterol (plantsterol), has been proven to relieve inflammatory response and control ruminal fermentation after high-grain diets consumption (Xia et al, 2020). Additional, Naringin, a type of citrus flavonoid with proven antioxidant properties, reduces the discomfort that might be associated with damage to the ruminal wall in cases of subclinical acidosis (Lopez-Campos et al, 2010).…”