Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes

Lee, Ho Seon; Heo, Chan Uk; Song, Young-Chae; Lee, Kyeong; Choi, Chang‐Ik

doi:10.1007/s12272-023-01432-7

Cited by 26 publications

(14 citation statements)

References 59 publications

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“…Studies have shown that AICAR induces AMPK activation, increases UCP1 expression, and induces a transition to beige adipocytes in white adipose tissue ( H.J. Kim et al, 2022 ; Lee et al, 2023 ). However, the AMPK inhibitor CC reversed this phenomenon ( Lee et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway

Xu,

Zhang,

Wang

et al. 2024

Current Research in Food Science

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Section: Discussionmentioning

confidence: 99%

Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway

Xu,

Zhang,

Wang

et al. 2024

Current Research in Food Science

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“…However, follow-up studies showed that it can also be expressed in white adipose tissue [ 118 ]. Currently, the ability of progenitor cells, as well as mature adipocytes, to differentiate into a model resembling the brown cell profile has been demonstrated, and when it occurs in white adipocytes, it is known as the browning of white adipose tissue [ 111 , 115 , 119 ].…”

Section: Discussionmentioning

confidence: 99%

PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study

Lobato,

Castillo-Granada,

Bucio-Pacheco

et al. 2024

Heliyon

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“…The average values of three replicates for each concentration were obtained. These data were then used to construct a naringin standard curve[10].…”

Section: Methodsmentioning

confidence: 99%

“…(UV Visible Spectrophotometer, UV-6300 , Meipeda Instrument Co., Ltd, Shanghai ,China).The average values of three replicates for each concentration were obtained. These data were then used to construct a naringin standard curve [10].…”

Section: Establishment Of a Naringin Standard Curvementioning

confidence: 99%

Extraction of naringin dihydrochalcone and its effect on reducing blood lipid levels in vitro

Tian,

Li,

et al. 2024

Preprint

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Response surface methodology (RSM) was used to optimize the extraction process of naringin. The central component design included three parameters of extraction, namely, temperature (X1), solid-liquid ratio (X2), and extraction time (X3). The optimum extraction temperature was 67?; the ratio of material to liquid was 54:1mL/g, and the extraction time was 2.8h. According to the best extraction conditions, naringin was processed to verify the accuracy of the model. Five parallel experiments were set up, and a yield of 32.48 mg/g naringin was obtained, that was equivalent to the predicted yield of 32.56 mg/g. Naringin was purified to obtain naringin-refined products using DM101 macroporous adsorption resin. Naringin dihydrochalcone was synthesized following catalytic hydrogenation of purified naringin. The structures of naringin and naringin dihydrochalcone were determined via Fourier infrared spectrometer and nuclear magnetic resonance spectrometry. Evaluate the ability of naringin dihydrochalcone to bind with glycine bile sodium and bovine bile sodium by simulating the gastrointestinal environment in vitro. Further focusing on HepG2 cells, a high cholesterol induced high-fat HepG2 cell model was established. We measured the effects of different concentrations of naringin dihydrochalcone on intracellular lipids in denatured HepG2 cells and further validated the lipid-lowering effect of naringin at the cellular level. The results showed that naringin dihydrochalcone has potential application in functional foods for lowering blood lipids.

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Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes

Cited by 26 publications

References 59 publications

Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway

Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway

PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study

Extraction of naringin dihydrochalcone and its effect on reducing blood lipid levels in vitro

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