Naringin reduces fat deposition by promoting the expression of lipolysis and β-oxidation related genes

Wang, Jing; Wang, Qi; Zhu, Siyuan; Huang, Jinxiu; Liu, Zuohua; Qi, Renli

doi:10.1016/j.orcp.2022.11.004

Cited by 6 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Atherosclerosis (AS) is a chronic inflammatory vascular disease driven by risk factors, lipid metabolism disorders as the pathological basis of AS, early arterial lesions starting from the intima, initial deposition of lipoproteins in the vascular wall, endothelium activation and expression of chemokines and adhesion molecules leading to leukocyte recruitment and infiltration into the subendothelium, and subsequent accumulation of cholesterol and low-density lipoprotein (LDL) into macrophages in the arterial wall [ 98 , 99 ], which eventually leads to thickening and hardening of the artery wall, narrowing of the lumen of the vessel, and even blockage. Naringin has been shown to lower cholesterol and triglyceride (TG), promote lipolysis, and regulate fatty acid β oxidation in a dose-dependent manner [ [100] , [101] , [102] , [103] , [104] ]. Various studies involved in vitro and in vivo models have shown that naringin has a positive effect on inhibiting AS progression.…”

Section: Resultsmentioning

confidence: 99%

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Peng,

Qu,

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Peng,

Qu,

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…However, it has been shown that the suppressive action of insulin occurs when adipocyte cultures are exposed to insulin in the presence of high glucose levels [ 60 ], which we have not previously reported in this experimental model [ 61 ]. Furthermore, some flavonoids that reduce IL-1β and MCP-1 concentrations in adipose tissue increase those of HSL [ 62 ]. Thus, it could be that the high levels of IL-1β and MCP-1 found in this study affect the expression of this lipase.…”

Section: Discussionmentioning

confidence: 99%

Changes in Lipid Metabolism Enzymes in Rat Epididymal Fat after Chronic Central Leptin Infusion Are Related to Alterations in Inflammation and Insulin Signaling

Casado

Canelles

Arilla‐Ferreiro

et al. 2023

IJMS

View full text Add to dashboard Cite

Leptin inhibits food intake and reduces the size of body fat depots, changing adipocyte sensitivity to insulin to restrain lipid accrual. This adipokine may modulate the production of cytokines that could diminish insulin sensitivity, particularly in visceral adipose tissue. To explore this possibility, we examined the effects of chronic central administration of leptin on the expression of key markers of lipid metabolism and its possible relationship with changes in inflammatory- and insulin-signaling pathways in epididymal adipose tissue. Circulating non-esterified fatty acids and pro- and anti-inflammatory cytokines were also measured. Fifteen male rats were divided into control (C), leptin (L, icv, 12 μg/day for 14 days), and pair-fed (PF) groups. We found a decrease in the activity of glucose-6-phosphate dehydrogenase and malic enzyme in the L group, with no changes in the expression of lipogenic enzymes. A reduction in the expression of lipoprotein lipase and carnitine palmitoyl-transferase-1A, together with a decrease in the phosphorylation of insulin-signaling targets and a low-grade inflammatory pattern, were detected in the epididymal fat of L rats. In conclusion, the decrease in insulin sensitivity and increased pro-inflammatory environment could regulate lipid metabolism, reducing epididymal fat stores in response to central leptin infusion.

show abstract

Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation

Zhao,

Hu,

Wang

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Current research efforts in polymer and nanotechnology applications are primarily focused on cargo delivery to enhance the therapeutic index, with limited attention being paid to self‐molecularly targeted nanoparticles, which may also exhibit significant therapeutic potential. Long‐term and anomalous lipid accumulation in the liver is a highly relevant factor contributing to liver diseases. However, the development of the reliable medications and their pharmacological mechanisms remain insufficient. Herein, a polyguanide nanoinhibitors (PGNI) depot is constructed by copolymerizing biguanide derivatives in different proportions onto prepolymers. The nanoinhibitors for their ability to ameliorate lipid accumulation in vitro and in vivo is screened, and subsequently demonstrated that covalently polymeric guanidine chains exhibit superior efficacy in ameliorating hepatic lipid accumulation via heterogeneous mechanisms compared to small‐molecule guanidine. It is found that PGNIs stabilize guanidine metabolism in the liver, preferably for biosafety. More importantly, PGNI is ingested and localized in hepatocyte lysosomes and is locked to interact with vesicular adenosine triphosphatase (V‐ATPase) on lysosomes, leading to the inhibition of V‐ATPase and lysosomal acidification, thereby activating the AMPK pathway, reducing fatty acid synthesis, and enhancing lipolysis and fatty acid oxidation. These results imply that polymer‐formed nanoparticles can serve as targeted inhibitors, offering a novel approach for therapeutic applications.

show abstract

Naringin reduces fat deposition by promoting the expression of lipolysis and β-oxidation related genes

Cited by 6 publications

References 43 publications

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Changes in Lipid Metabolism Enzymes in Rat Epididymal Fat after Chronic Central Leptin Infusion Are Related to Alterations in Inflammation and Insulin Signaling

Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation

Contact Info

Product

Resources

About