Narkosemedikamente – Analgesieren, sedieren, relaxieren

Küßner, Tobias; Popp, Erik

doi:10.1055/s-0042-103608

Cited by 2 publications

(2 citation statements)

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“…Sufentanil is 1 of the synthetically produced opioids and the most potent opioid approved in Germany. [21] Sufentanil binds to both the µ- and the κ-receptor, but with a higher affinity to the µ-opioid receptor. [15,20,22] It is preferred in intensive care medicine because of its pronounced analgesia and sedation component, as well as its shorter context-sensitive half-life.…”

Section: Introductionmentioning

confidence: 99%

Pain management in surgical intensive care patients: A retrospective observational research

et al. 2022

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Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU). Adequate analgesia is essential to achieve positive outcomes. There were differences in pain management between patients with and without sepsis or septic shock. The release of inflammatory mediators, especially cytokines, in sepsis or septic shock decreases the pain threshold. Septic intensive care patients probably require higher doses of opioids than do non-septic patients. A retrospective observational study was carried out in an anesthesiologic intensive care unit from January 1, 2014 to June 30, 2016. Patients were divided into 4 groups according to the following criteria: sepsis ("yes/no" and communication ability "yes/no"). After adjusting for the number of cases using the pairing method, a total of 356 patients were recruited. The endpoint of our study was defined as the "total opioid dose". Statistical evaluations were performed using t tests and 2-factor analysis of variance. There was a significant difference in opioid doses between communicative and non-communicative ICU patients F(1, 352) = 55.102, P < .001). This effect was observed in the ICU patients with and without sepsis. The mean sufentanil dose was significantly higher in noncommunicative patients than in communicative patients group (E(1, 352) = 51.435, P < .001, partial ƞ 2 = 0.144). The effect of higher opioid-(F(1, 352) = 1.941, P = .161) and sufentanil (F(1, 352) = 1.798, P = .342) requirement was not statistically significant due to sepsis. The hypothesis that sepsis decreases the pain threshold could not be proven in this study. The effect of a higher opioid requirement is not directly caused by sepsis but by communication ability. Furthermore, we were able to show through our investigations and especially through the data of the pain recording instruments that the septic and non-septic intensive care patients receive sufficient pain therapy treatment in our ICU. Regular pain evaluations should be performed on patients in the ICUs who are able to communicate and those who are not.

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Section: Introductionmentioning

confidence: 99%

Pain management in surgical intensive care patients: A retrospective observational research

et al. 2022

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“…Sufentanil is one of the synthetically produced opioids and is the most potent opioid approved in Germany [17]. Sufentanil binds to both the µ-and the κ-receptor, but with a higher a nity to the µ-opioid receptor [11,16,18].…”

Section: Introductionmentioning

confidence: 99%

“Pain Management in Intensive Care Patients, a Retrospective Observational Research.”

Dinse

Bucher

Burgdorff

et al. 2021

Preprint

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Background Sepsis and septic shock are the most common causes of death in non-cardiac surgery intensive care units. The treatment of sepsis is difficult. Adequate analgesia is essential for a positive outcome. There are differences in pain management between septic and non-septic patients. Septic ICU patients receive higher doses of opioids than non-septic ICU patients. Methods A retrospective observational study was carried out in an anesthesiological intensive care from 1.1.2014 to 30.6.2016. The cases were divided into four different groups according to the criteria: Sepsis “yes/no” and communication ability “yes/no”. After adjusting the number of cases by pairing method, 356 cases were recruited. The endpoint of our study was defined as the "total opioid dose". A statistical evaluation was carried out by T-tests and two-factor variance analyses. Results There is a significant difference in opioid dose between communicative and non-communicative ICU patients. The mean sufentanil dose is significantly higher in the non-communicative patients than in the communicative patients. Sepsis has no significant effect on the dose of sufentanil. Conclusion The hypothesis that sepsis decreases the pain threshold could not be proven in this study. The effect of the higher opioid requirement is not directly caused by sepsis, but by the factor of communication ability. Furthermore, we were able to show through our investigations and especially through the data of the pain recording instruments that the septic and non-septic intensive care patients receive sufficient pain therapy treatment.

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Narkosemedikamente – Analgesieren, sedieren, relaxieren

Cited by 2 publications

References 0 publications

Pain management in surgical intensive care patients: A retrospective observational research

Pain management in surgical intensive care patients: A retrospective observational research

“Pain Management in Intensive Care Patients, a Retrospective Observational Research.”

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