Narrative Review: Hepatobiliary Disease in Type 2 Diabetes Mellitus

Tolman, Keith G.; Fonseca, Vivian; Tan, Meng H.; Dalpiaz, Anthony

doi:10.7326/0003-4819-141-12-200412210-00011

Cited by 109 publications

(74 citation statements)

References 125 publications

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“…Hepatobiliary disorders, such as inflammation, necrosis or fibrosis of non-alcoholic fatty liver disease, cirrhosis, hepatocellular carcinoma, hepatitis C, acute liver failure, and cholelithiasis are complications of diabetes [6,7].Therefore combating diabetes mellitus goes far beyond mere glycaemic control.…”

Section: Introductionmentioning

confidence: 99%

<i>Ocimum Gratissimum</i> Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats

Onaolapo

2012

Macedonian Journal of Medical Sciences

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Aim: Hepatoprotective effects of Ethanolic extract Ocimum gratissimum leaves (O. gratissimum) in streptozotocin-induced diabetic rats was studied. Material and Methods:Thirty-six adult rats were assigned into six groups (A, B, C, D, E and F) of six rats each. Group A was the control, while diabetes was induced in groups B, C, D, E and F. Fasting blood glucose was determined and rats with blood glucose concentration >18.0 mmol/L were considered diabetic. Group A (non diabetic control) and F (diabetic control) received normal saline orally, group B received a Metformin at 25 mg/kg while groups C, D and E had O. gratissimum at 400, 600 and 800 mg/ kg. Treatment was daily for a period of 28 days for all groups. Fasting blood glucose was monitored weekly, serum levels of Alanine transaminase (ALT) and Aspartate transaminase (AST) were measured on day twenty eight. Animals were sacrificed, liver sections processed for histological study. Statistical analysis was carried out using a one way ANOVA followed by a post-hoc test.Results: Results showed reduction in blood sugar and increase in biochemical and histologic markers of hepatic injury. Conclusion:Ethanolic extract of O. gratissimum causes dose dependent hepatic injury despite its glucose lowering ability.

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Section: Introductionmentioning

confidence: 99%

<i>Ocimum Gratissimum</i> Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats

Onaolapo

2012

Macedonian Journal of Medical Sciences

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“…In recent years, a positive association between hepatitis C virus (HCV) infection and diabetes mellitus (DM) had been reported in a number of clinical studies [1][2][3][4] . It is now clear that hepatitis C conveys a risk for developing DM, in particular type 2 [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Association of hepatitis C virus infection and diabetes in central Tunisia

Kaabia¹,

Jazia²,

Slim³

et al. 2009

WJG

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AIM:To investigate hepatitis C virus (HCV) seropreva lence in Tunisian patients with diabetes mellitus and in a control group. METHODS:A crosssectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes (452 male, 817 female) and 1315 non diabetic patients, attending health centers in Sousse, Tunisia. HCV screening was performed in both groups using a fourthgeneration enzyme immunoassay. RESULTS:In the diabetic group, 17 (1.3%) were found to be HCVinfected compared with eight (0.6%) in the control group, although the difference was not significant (P = 0.057). Quantitative PCR was performed in 20 patients. Eleven patients were positive and showed HCV genotype 1b in all cases. CONCLUSION:Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia, with no significant difference between the groups.

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“…By affecting glycogen and lipid metabolism, diabetes causes structural and functional abnormalities in the liver (6). Studies have shown that hepatobiliary disorders, such as infl ammation, necrosis and acute liver failure can follow diabetes (7,8).…”

Section: Introductionmentioning

confidence: 99%

The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury

Taşlıdere¹,

Gül²,

Elbe³

et al. 2016

BLL

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The aim of the present study was to clarify the role of oxidative stress in streptozotocin induced liver injury and the possible protective effect of caffeic acid phenethyl ester (CAPE) using histological and biochemical parameters. 32 male Wistar rats were divided into 4 groups as follows: Group 1: Control animals, Group 2: Control animals given CAPE Group 3: STZ-induced diabetic animals (DM group), Group 4: STZ-induced diabetic rats given CAPE (DM+CAPE group). All the injections started on the same day of single-dose STZ injection and continued for 20 days. At the end of this period, livers were removed and processed for routine histological procedures. Biochemical parameters and morphological changes were examined. In DM group, blood glucose levels were signifi cantly increased compared with the control group. Signifi cant increases in tissue malondialdehyde (MDA) level and decreases in superoxide dismutase (SOD) and total glutathione (GSH) activities were detected in DM group. Administration of CAPE signifi cantly reduced these values. STZ-induced histopathological alterations including infl ammatory cell infi ltration around portal triad, congestion, loss of glycogen in the hepatocytes. Additionally, degenerative cellular alterations, such as numerous vacuolizations including myelinic fi gure formation, pyknotic nuclei with peripheral localization of heterochromatin condensation and mitochondrial elongation were observed in cytoplasm of hepatocytes. CAPE signifi cantly reduced these histopathological changes. Our results indicate that CAPE should be considered in the prevention of oxidative stress in diabetic liver (Tab. 3, Fig. 4, Ref. 47). Text in PDF www.elis.sk. KEY WORDS: caffeic acid phenethyl ester, streptozotocin, liver.

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Narrative Review: Hepatobiliary Disease in Type 2 Diabetes Mellitus

Cited by 109 publications

References 125 publications

<i>Ocimum Gratissimum</i> Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats

<i>Ocimum Gratissimum</i> Linn Causes Dose Dependent Hepatotoxicity in Streptozotocin-Induced Diabetic Wistar Rats

Association of hepatitis C virus infection and diabetes in central Tunisia

The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury

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