Narrative Review of the COVID-19 Pandemic’s First Two Years in Italy

Beccia, F; Pilla, Andrea Di; Causio, Francesco Andrea; Federico, Bruno; Specchia, Maria Lucia; Favaretti, Carlo; Boccia, Stefania; Damiani, Gianfranco

doi:10.3390/ijerph192315443

Cited by 14 publications

(10 citation statements)

References 60 publications

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“…COVID-19 has shaped the world as we know it, and COVID-19 vaccination, given the increasing possibility of it becoming a seasonal vaccination, is still an ever-present issue to be researched [ 64 ]. We conducted a retrospective pharmacovigilance study on the safety of the BNT162b2 (Comirnaty) vaccine among healthcare workers (HCWs) in a large Italian teaching hospital.…”

Section: Discussionmentioning

confidence: 99%

BNT162b2 COVID-19 Vaccine Safety among Healthcare Workers of a Tertiary Hospital in Italy

et al. 2023

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Millions of people have died because of the COVID-19 pandemic. The vaccination campaign helped tackle the pandemic and saved millions of lives. In a retrospective pharmacovigilance study, we explored the safety of the BNT162b2 (Comirnaty) vaccine among healthcare workers (HCWs) in a large Italian teaching hospital, and 2428 Adverse Events Reports (AERs) filed by HCWs after the administration of the first dose of vaccine were collected and analyzed, reporting the results quantitively and comparing them to the vaccine Summary of Product Characteristics (SPC). Spearman’s correlation coefficients were computed to investigate the correlation among reported adverse effects, and recurrent clusters of symptoms were investigated through the Principal Component Analysis (PCA) and k-means Cluster Analysis. The BNT162b2 vaccine’s safety profile was favorable, with predominant reports of early onset, mild, non-serious and short-term resolved symptoms. We observed higher than the expected frequency for various non-serious undesirable effects, especially among those listed and classified as less common in the SPC. Furthermore, we identified three clusters of adverse effects that were frequently reported together, defined by the presence/absence of fatigue, malaise, localized pain, chills, pyrexia, insomnia, nausea and injection site pain. Post-marketing pharmacovigilance activities, together with targeted public health interventions, can be valuable tools to promote vaccination and improve the control of the spread of the pandemic, especially in sensitive settings and populations such as hospitals and healthcare professionals.

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Section: Discussionmentioning

confidence: 99%

BNT162b2 COVID-19 Vaccine Safety among Healthcare Workers of a Tertiary Hospital in Italy

et al. 2023

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“…Italy's population is among the oldest in the world, making it especially vulnerable to the virus, disproportionately affecting the elderly. In addition, the spread of the virus was facilitated by high population density in cities and high mobility within and between regions [36].…”

Section: Background On Covid-19 In Italymentioning

confidence: 99%

Epidemiological Implications of War: Machine Learning Estimations of the Russian Invasion’s Effect on Italy’s COVID-19 Dynamics

Chumachenko,

Dudkina,

Chumachenko

et al. 2023

Computation

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Background: The COVID-19 pandemic has profoundly transformed the global scenario, marked by overwhelming infections, fatalities, overburdened healthcare infrastructures, economic upheavals, and significant lifestyle modifications. Concurrently, the Russian full-scale invasion of Ukraine on 24 February 2022, triggered a severe humanitarian and public health crisis, leading to healthcare disruptions, medical resource shortages, and heightened emergency care needs. Italy emerged as a significant refuge for displaced Ukrainians during this period. Aim: This research aims to discern the impact of the Russian full-scale invasion of Ukraine on the COVID-19 transmission dynamics in Italy. Materials and Methods: The study employed advanced simulation methodologies, particularly those integrating machine learning, to model the pandemic’s trajectory. The XGBoost algorithm was adopted to construct a predictive model for the COVID-19 epidemic trajectory in Italy. Results: The model demonstrated a commendable accuracy of 86.03% in forecasting new COVID-19 cases in Italy over 30 days and an impressive 96.29% accuracy in estimating fatalities. When applied to the initial 30 days following the escalation of the conflict (24 February 2022, to 25 March 2022), the model’s projections suggested that the influx of Ukrainian refugees into Italy did not significantly alter the country’s COVID-19 epidemic course. Discussion: While simulation methodologies have been pivotal in the pandemic response, their accuracy is intrinsically linked to data quality, assumptions, and modeling techniques. Enhancing these methodologies can further their applicability in future public health emergencies. The findings from the model underscore that external geopolitical events, such as the mass migration from Ukraine, did not play a determinative role in Italy’s COVID-19 epidemic dynamics during the study period. Conclusion: The research provides empirical evidence negating a substantial influence of the Ukrainian refugee influx due to the Russian full-scale invasion on the COVID-19 epidemic trajectory in Italy. The robust performance of the developed model affirms its potential value in public health analyses.

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“…In December 2019, the world saw the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), which can range from an asymptomatic infection to acute respiratory distress syndrome (ARDS) [1,2]. The new coronavirus disease 2019 (COVID-19) put health systems in serious difficulties, infecting over 635 million people with more than 6.6 million deaths [3,4]. Nowadays, as the pandemic persists, more than 30% of people infected with COVID-19, including asymptomatic cases, and approximately 80% of patients hospitalized for COVID-19 have reported long COVID, or post COVID-19 condition (PCC) after infection [5].…”

Section: Introductionmentioning

confidence: 99%

Whole-Body Cryostimulation in Post-COVID Rehabilitation for Patients with Obesity: A Multidisciplinary Feasibility Study

Fontana,

Alito,

Piterà

et al. 2023

Biomedicines

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Background: A post-COVID condition can reduce activity and quality of life, resulting in a significant socioeconomic and health burden. Understanding its impact on patients’ health is important for the development of personalized rehabilitation interventions. An independent association between obesity and post-COVID condition was found because of complications and comorbidities. Methods: Sixteen patients with obesity and post-COVID symptoms (i.e., dyspnea, pain, poor sleep quality, muscle fatigue), admitted to the Istituto Auxologico Italiano, Piancavallo (VB), Italy, were recruited for a four-week rehabilitation program including conventional exercise therapy, nutritional intervention, psychological support and whole-body cryostimulation (WBC). Results: All participants attended all sessions of the program. Anthropometric data showed statistically significant changes in weight, waist circumference and body mass index. Biochemical analyses showed significant reductions in lipid and inflammatory profiles. There was a significant improvement in physical performance, reduction in pain and improvement in psychological well-being. Conclusion: A multidisciplinary rehabilitation protocol including WBC, designed for patients with obesity and a post-COVID condition, is safe and feasible. The overall improvements demonstrate that multidisciplinary rehabilitation was effective on post COVID patients and suggest that the use of WBC is safe and could play a role as a booster in rehabilitation programs.

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Narrative Review of the COVID-19 Pandemic’s First Two Years in Italy

Cited by 14 publications

References 60 publications

BNT162b2 COVID-19 Vaccine Safety among Healthcare Workers of a Tertiary Hospital in Italy

BNT162b2 COVID-19 Vaccine Safety among Healthcare Workers of a Tertiary Hospital in Italy

Epidemiological Implications of War: Machine Learning Estimations of the Russian Invasion’s Effect on Italy’s COVID-19 Dynamics

Whole-Body Cryostimulation in Post-COVID Rehabilitation for Patients with Obesity: A Multidisciplinary Feasibility Study

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