Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes

Cheng, Hsiu-Chung; Chang, Tsung‐Kun; Su, Wei‐Chih; Tsai, Hsiang‐Lin; Wang, Jaw‐Yuan

doi:10.1016/j.tranon.2021.101089

Cited by 45 publications

(42 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study (Figure 6), AKT, iNS, eNOS, and MAPK were downregulated in the model group compared with the control group and significantly upregulated in the GP and MET groups compared with the model group. These results were in line with the data presented in previous reports (Alghanem et al, 2021;Cheng et al, 2021). As reported, the AGE-RAGE signaling pathway is closely associated with T2DM and inflammation (Syed et al, 2020).…”

Section: Regulation Of Pi3k/akt and Age-rage Signaling In Vivosupporting

confidence: 93%

Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism of Gynura procumbens on Type 2 Diabetes

Guo

Ouyang²,

Liu

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Gynura procumbens (GP) is a perennial herbal medicine and food homologous plant, which has been reported to have a good hypoglycemic effect. However, its active components and underlying mechanism of action are not clear. Here, we aimed to confirm the effects of GP on type 2 diabetes (T2DM) from several different aspects. We used UPLC/Q-TOF MS to analyze the metabolic patterns, which included blood samples of clinical subjects and db/db mice to screen for serum metabolic markers and metabolic pathways. We also used network pharmacology to study GP targets in the treatment of T2DM. Data from endogenous metabolites in plasma showed that two common pathways, including glycerol phosphate metabolism and retinol metabolism, were identified in plasma samples of the groups. Finally, Western blot analysis was used to verify the expression of proteins in the PI3K/AKT and AGE–RAGE signaling pathways. The protein expression of AKT, eNOS, iNS, and MAPK was significantly upregulated, and the expression of caspase-8 and caspase-3 was significantly downregulated. Thus, our findings indicated that GP could alleviate insulin resistance by regulating biometabolic markers and key proteins in the PI3K/AKT and AGE–RAGE signaling pathways to treat T2DM.

show abstract

Section: Regulation Of Pi3k/akt and Age-rage Signaling In Vivosupporting

confidence: 93%

Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism of Gynura procumbens on Type 2 Diabetes

Guo

Ouyang²,

Liu

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Western blot analysis confirmed that PLEK2 knockdown significantly suppressed activation of the PI3K/AKT/mTOR pathway by decreasing the phosphorylation of PI3K and AKT, which resulted in the suppression of EMT. However, the addition of insulin-like growth factor 1, an agonist of the PI3K/AKT pathway ( 24 ), was able to reverse the effects of PLEK2 knockdown. In addition, overexpression of PLEK2 activated the PI3K/AKT/mTOR pathway and EMT process, which was reversed by LY 294002, an inhibitor of the PI3K/AKT pathway ( 25 ) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway

et al. 2021

View full text Add to dashboard Cite

Increasing evidence suggest that pleckstrin-2 (PLEK2) acts as an oncogene in several malignancies. The present study aimed to investigate the effects of PLEK2 on osteosarcoma (OS) tumorigenesis and metastasis. PLEK2 expression in OS was analyzed via bioinformatics, reverse transcription-quantitative PCR, western blot and immunohistochemistry analyses. The Cell Counting Kit-8 (CCK-8), colony formation and EdU assays were performed to assess the role of PLEK2 in OS cell proliferation. The pro-metastatic effects of PLEK2 were assessed via the Transwell and wound healing assays. In addition, the PLEK2 downstream pathway was analyzed via bioinformatics analysis and verified via western blot analysis. The results demonstrated that PLEK2 expression was upregulated in both OS cell lines and specimens. The results of the CCK-8, colony formation and EdU assays demonstrated that PLEK2 promoted OS cell proliferation in vitro. The in vivo experiments further demonstrated that PLEK2 knockdown significantly suppressed OS growth. In addition, the Transwell and wound healing assays indicated that PLEK2 promoted OS invasiveness in vitro, which was induced by the activation of the epithelial-to-mesenchymal transition process. Bioinformatics analysis revealed that PLEK2 can activate the phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) pathway, which was verified via western blot analysis. Taken together, the results of the present study suggest that PLEK2 may play a tumor-promoting role in OS via the PI3K/AKT signaling pathway.

show abstract

“…In the current study, patients with T2DM remission improved in terms of their overall survival after CRC surgery, and T2DM remission improved overall survival in gastric cancer patients ( 14 ). The mechanism of improved overall survival remains unclear and might be related to the upregulation of AMP-activated protein kinase, which causes cell cycle arrest in the Gap 1-S (G1-S) phase and inhibits the mTOR pathway ( 12 ). Furthermore, modification of lifestyle, dietary restrictions and physical activity are measures for reducing mortality ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that T2DM could improve the incidence of CRC (8,9), and mortality and complications would increase when patients with concurrent CRC and T2DM underwent CRC surgery (10). Furthermore, T2DM has been shown to have significant effects on chemoresistance, and pre-existing T2DM patients decreases overall survival and increases the risk of relapse survival after CRC surgery as well (11,12).…”

Section: Introductionmentioning

confidence: 99%

Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

et al. 2021

View full text Add to dashboard Cite

PurposeThe purpose of the current study was to evaluate the impact of colorectal cancer (CRC) surgery on type 2 diabetes mellitus (T2DM) and to analyze the change in T2DM on overall survival after CRC surgery.MethodsPatients who underwent CRC surgery were retrospectively enrolled from January 2013 to December 2019. The status of T2DM pre- and 1-year after CRC surgery was recorded, and predictive factors for T2DM remission and overall survival were analyzed.ResultsA total of 296 patients were included in this study. Thirty-eight patients experienced remission of T2DM 1 year after CRC surgery, and the remission rate was 12.8%. Weight loss was significantly higher in the T2DM remission group (p = 0.038), and the T2DM duration was significantly shorter in the T2DM remission group (p = 0.015). In the multivariate logistic regression analysis, higher weight loss (p = 0.046, odds ratio = 1.060, 95% CI = 1.001–1.122) and shorter T2DM duration (p = 0.019, odds ratio = 1007, 95% CI = 1.001–1.014) were predictive factors for remission of T2DM. Furthermore, in multivariate Cox regression analysis, lower TNM stage (p = 0.000, odds ratio = 2.147, 95% CI = 1.474–3.128) and T2DM remission (p = 0.033, odds ratio = 2.999, 95% CI = 1.091–8.243) were the predictive factors for better overall survival.ConclusionPatients with concurrent CRC and T2DM had a 12.8% remission 1 year after CRC surgery. Higher weight loss and shorter T2DM duration contributed to T2DM remission, and patients with T2DM remission could improve in terms of their overall survival.

show abstract

Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes

Cited by 45 publications

References 81 publications

Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism of Gynura procumbens on Type 2 Diabetes

Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism of Gynura procumbens on Type 2 Diabetes

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway

Improvement of Diabetes Mellitus After Colorectal Cancer Surgery: A Retrospective Study of Predictive Factors For Type 2 Diabetes Mellitus Remission and Overall Survival

Contact Info

Product

Resources

About