Narrow Band Imaging‐guided resection of oral cavity cancer decreases local recurrence and increases survival

Abstract

Resection to NBI-defined margins improves survival rates and decreases recurrence rates of OSCC compared to traditional methods and should be adopted as the new gold standard for determining mucosal surgical margins for treatment of oral cavity cancer. These promising results have set the scene for a multicentred randomised controlled trial comparing NBI to WL currently underway.

The economic burden of oral squamous cell carcinoma in Australia

“…It is well accepted that 20% of patients who have their primary tumour completely excised with no microscopic evidence of residual disease, still suffer from local recurrence . There is an urgent clinical and economical need to investigate novel techniques and technologies that will reduce local recurrence rates in patients with oral cancer …”

“…29 There is an urgent clinical and economical need to investigate novel techniques and technologies that will reduce local recurrence rates in patients with oral cancer. [30][31][32][33] There In terms of costing inclusions and exclusions, psychology and social work input were not included due to insufficient information about the nature of these visits. We know that oral cancer patients face considerable psychological, financial and social stressors [34][35][36] associated with their diagnosis and treatment, and the economic burden of this is not reflected in this study.…”

Mass spectrometry in the palm of your hand: Future applications of in vivo tissue analysis

“…Improved definition of surgical margins is a recognised area for improvement. Ambient MS may provide confirmatory molecular evidence, which complements visual adjuncts like Narrow Band Imaging or optical fluorescence imaging (Boppart et al., ; Farah, ; Kordbacheh, Bhatia, & Farah, ). If successfully implemented, the advantages for the surgeon of real‐time unambiguous feedback on clear margins are incontrovertible in comparison with current practice.…”

“…The same approach could be used in the context of surgical management of oral potentially malignant disorders (OPMD) amenable to surgery from a practical perspective, and for which surgery meets the needs of the patient. Regardless of the surgical approach, and the strength of evidence for or against surgical intervention for management of OPMD, it is clear that better outcomes are expected when a lesion can be fully visualised and completely excised with clear margins (Farah, ; Farah, Kordbacheh, John, Bennett, & Fox, ). Adoption of an approach based on the MasSpec Pen could very well decrease recurrence of OPMD, provide better patient outcomes, and facilitate surveillance of oral tissues following surgical intervention by guaranteeing removal of diseased tissue to facilitate long‐term observation of clinically normal‐appearing remaining tissue (Dost, Lê Cao, Ford, Ades, & Farah, ).…”

A keratinised lump on the lateral surface of the tongue

“…OSCCs double in size every three months, 9 so it is imperative that general practitioners initiate appropriate referral pathways for suspected OSCC. The use of new optical and surgical approaches can improve disease-free survival 10 and reduce the economic burden of OSCC, 11 but early diagnosis remains the primary prognostic factor.…”