Narrow band imaging of squamous cell carcinoma tumors using topically delivered anti‐EGFR antibody conjugated gold nanorods

Puvanakrishnan, Priyaveena; Diagaradjane, Parmeswaran; Kazmi, S. M. Shams; Dunn, Andrew K.; Krishnan, Sunil; Tunnell, James W.

doi:10.1002/lsm.22019

Cited by 29 publications

(20 citation statements)

References 37 publications

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“…2,26 In addition, their strong NIR plasmon peak (Figure 1) enables them to scatter, absorb or luminesce when excited in the NIR. 27,28 Recently, we demonstrated that systemically delivered GNSs passively accumulated in human colon tumors and served as excellent absorption-based contrast agents for wide-field tumor imaging. 29 Smaller particles have high permeation/diffusion through tumor interstitium and correspondingly, higher clearance to surrounding normal tissue (where they are likely to be cleared).…”

Section: Discussionmentioning

confidence: 99%

In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

Puvanakrishnan

Park

Chatterjee

et al. 2012

IJN

Self Cite

103

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Gold nanoparticles (GNPs) have gained significant interest as nanovectors for combined imaging and photothermal therapy of tumors. Delivered systemically, GNPs preferentially accumulate at the tumor site via the enhanced permeability and retention effect, and when irradiated with near infrared light, produce sufficient heat to treat tumor tissue. The efficacy of this process strongly depends on the targeting ability of the GNPs, which is a function of the particle's geometric properties (eg, size) and dosing strategy (eg, number and amount of injections). The purpose of this study was to investigate the effect of GNP type and dosing strategy on in vivo tumor targeting. Specifically, we investigated the in vivo tumortargeting efficiency of pegylated gold nanoshells (GNSs) and gold nanorods (GNRs) for single and multiple dosing. We used Swiss nu/nu mice with a subcutaneous tumor xenograft model that received intravenous administration for a single and multiple doses of GNS and GNR. We performed neutron activation analysis to quantify the gold present in the tumor and liver. We performed histology to determine if there was acute toxicity as a result of multiple dosing. Neutron activation analysis results showed that the smaller GNRs accumulated in higher concentrations in the tumor compared to the larger GNSs. We observed a significant increase in GNS and GNR accumulation in the liver for higher doses. However, multiple doses increased targeting efficiency with minimal effect beyond three doses of GNPs. These results suggest a significant effect of particle type and multiple doses on increasing particle accumulation and on tumor targeting ability.

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Section: Discussionmentioning

confidence: 99%

In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

Puvanakrishnan

Park

Chatterjee

et al. 2012

IJN

Self Cite

103

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“…However, gold nanoparticles have widely been used for targeted molecular contrast for various applications (28). Tumors are also often passively labeled with gold nanoparticles via the enhanced permeability and retention effect (29).…”

Section: Photothermal Octmentioning

confidence: 99%

Molecular Imaging in Optical Coherence Tomography

Mattison¹,

Kim²,

Park³

et al. 2015

CMI

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Optical coherence tomography (OCT) is a medical imaging technique that provides tomographic images at micron scales in three dimensions and high speeds. The addition of molecular contrast to the available morphological image holds great promise for extending OCT’s impact in clinical practice and beyond. Fundamental limitations prevent OCT from directly taking advantage of powerful molecular processes such as fluorescence emission and incoherent Raman scattering. A wide range of approaches is being researched to provide molecular contrast to OCT. Here we review those approaches with particular attention to those that derive their molecular contrast directly from modulation of the OCT signal. We also provide a brief overview of the multimodal approaches to gaining molecular contrast coincident with OCT.

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“…have spearheaded this research, 106–108 which has also been pursued by the group of Tunnell. 109,110 The use of exogenous contrast agents may push the sensitivity and specificity of multiphoton imaging to a point where it can be relied upon in the clinic; however, the regulatory hurdles to the use of any exogenous image contrast agent are considerable.…”

Section: Applications Of Multiphoton Microscopy In Different Areasmentioning

confidence: 99%

Application of multiphoton microscopy in dermatological studies: A mini-review

Yew

Rowlands

2014

J. Innov. Opt. Health Sci.

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This review summarizes the historical and more recent developments of multiphoton microscopy, as applied to dermatology. Multiphoton microscopy offers several advantages over competing microscopy techniques: there is an inherent axial sectioning, penetration depths that compete well with confocal microscopy on account of the use of near-infrared light, and many two-photon contrast mechanisms, such as second-harmonic generation, have no analogue in one-photon microscopy. While the penetration depths of photons into tissue are typically limited on the order of hundreds of microns, this is of less concern in dermatology, as the skin is thin and readily accessible. As a result, multiphoton microscopy in dermatology has generated a great deal of interest, much of which is summarized here. The review covers the interaction of light and tissue, as well as the various considerations that must be made when designing an instrument. The state of multiphoton microscopy in imaging skin cancer and various other diseases is also discussed, along with the investigation of aging and regeneration phenomena, and finally, the use of multiphoton microscopy to analyze the transdermal transport of drugs, cosmetics and other agents is summarized. The review concludes with a look at potential future research directions, especially those that are necessary to push these techniques into widespread clinical acceptance.

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Narrow band imaging of squamous cell carcinoma tumors using topically delivered anti‐EGFR antibody conjugated gold nanorods

Cited by 29 publications

References 37 publications

In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

Molecular Imaging in Optical Coherence Tomography

Application of multiphoton microscopy in dermatological studies: A mini-review

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