Narrow-band imaging versus white light versus mapping biopsy for gastric intestinal metaplasia: a prospective blinded trial

Cresyl violet as a new contrast agent in probe‐based confocal laser endomicroscopy for in vivo diagnosis of gastric intestinal metaplasia

“…In our study, at least five biopsies were taken from each subject after informed consent, which consumed a lot of time and lead to longer examination time. Previous study has shown that the mean procedure time was 24.2 min when using narrow‐band imaging with mapping biopsies for detecting GIM . It is true that narrow‐band imaging with magnifying endoscopy could enable a highly accurate prediction of GIM but was limited to recognizing the macroscopic changes; pCLE allowed real‐time in vivo histological diagnosis of the mucosal layer at cellular and subcellular resolution during ongoing endoscopy with high accuracy.…”

“…Previous study has shown that the mean procedure time was 24.2 min when using narrow-band imaging with mapping biopsies for detecting GIM. 25 It is true that narrow-band imaging with magnifying endoscopy could enable a highly accurate prediction of GIM 3 but was limited to recognizing the macroscopic changes; pCLE allowed real-time in vivo histological diagnosis of the mucosal layer at cellular and subcellular resolution during ongoing endoscopy with high accuracy. To date, several studies have shown its diagnostic value for GIM.…”

Long‐term outcome of group D patients with negative serum anti‐Helicobacter pylori antibody and positive serum pepsinogen test in healthy Koreans

“…Second, gastric atrophy was assessed by endoscopy using conventional white‐light endoscopy. The diagnostic accuracy of conventional endoscopy has been reported to be relatively low compared with autofluorescence imaging . In general, the histological evaluation of EAG using biopsy specimens is considered to be a better method than simple endoscopic observation.…”

“…The diagnostic accuracy of conventional endoscopy has been reported to be relatively low compared with autofluorescence imaging. 45,46 In general, the histological evaluation of EAG using biopsy specimens is considered to be a better method than simple endoscopic observation. However, in some patients there was a fluctuation in the grade of atrophy and intestinal metaplasia, or the abrupt development of intestinal metaplasia.…”

The East in the West

“…This requires optimal equipment and good endoscopic assessment and characterization skills. This work has been developed by several Portuguese gastroenterologists during the last years [3][4][5][6][7][8]. The improvement in R0 resection rates in the study by Costa et al [2] may reflect improvements in all these factors.…”