Narrow Intercondylar Notch and Anterior Cruciate Ligament Injury in Female Nonathletes with Knee Osteoarthritis Aged 41–65 Years in Plateau Region

Abstract

Background:Few data are available concerning intercondylar notch dimensions in female nonathletes with knee osteoarthritis (OA) in plateau region. The aim of this study was to assess the relation of intercondylar notch morphology to anterior cruciate ligament (ACL) injuries in female nonathletes with knee OA aged 41–65 years from the Chinese Loess Plateau.Methods:The study was conducted on 330 patients with ACL injury (aged 31–65 years; 159 males, 171 females), 141 patients with OA (aged 31–65 years; 59 males, 82 females), and 89 female healthy controls (aged 41–65 years), and this evaluation included identifying the distribution of patients with OA or ACL injury and measuring the intercondylar notch width indexes (NWIs).Results:There was a significant rising trend in patients with OA (the Kellgren and Lawrence grade = 3) with ACL injury (OA-S + ACL) aged 41–65 years, especially in females. We found that the notches of OA-S + ACL had a smaller NWI compared with control and OA without ACL injury (OA-S-only, P = 0.000, 95% confidence interval [CI] = −0.059–−0.030; P = 0.000, 95% CI = −0.049–−0.016). A similar trend was found in notch shape index (NSI), but not in notch depth index and the cross-sectional area. The cutoff of NWI and NSI value was 0.26, and 0.65, and area under the receiver operating characteristic curve was 0.82, and 0.79, respectively. Further study displayed a significant correlation between a reduced NWI and NSI and OA-S + ACL (P = 0.000, χ2 = 14.012; P = 0.000, χ2 = 14.286).Conclusion:A narrower intercondylar notch and a plateau environment are risk factors of predisposing female nonathletes with knee OA to ACL injury aged 41–65 years.

Individual and Combined Anatomic Risk Factors for the Development of an Anterior Cruciate Ligament Rupture in Men: A Multiple Factor Analysis Case-Control Study

“…5 The cutoff values of 4.3° in men and 4.5° in women for MTS have ORs of 2.94 and 6.18, respectively. 6 Further, an increased LTS was associated with an increased ACL injury risk, with an OR of 1.12. 2 In addition, the lateral middle cartilage slope on MRI scans is a risk factor for an ACL injury, with a reported OR of 1.303.…”

“…In most of the studies, an NW between 10.4 and 22.5 mm, especially ≤17 mm, was associated with a significantly increased risk of ACL injuries. 6,10,25 On the other hand, in some studies, an NWI between 0.16 and 0.26 was associated with an ACL injury. 3,21 Also, a reduced tibial EW and tibial eminence volume (and associated NW-EW ratio) have been associated with an increased risk of ACL injuries.…”

“…The following morphological parameters were measured and calculated on coronal, sagittal, and axial MRI scans: NW, 8 NWI, 8 eminence width (EW), 28 eminence width index (EWI), 28,33 NW:EW ratio, 2 notch height, 2 NSI, 6 intercondylar notch angle–axial, 10 intercondylar notch angle–coronal, 10 axial lateral wall angle (LWA), 2 coronal LWA, 2 IRT, 32 alpha angle, 8 medial tibial depth (MTD), 7 MTS, 2,7 LTS, 2,7 coronal tibial slope, 8 femoral anteroposterior length, 31 lateral condylar anteroposterior distance (LCAP), 31 TPAP, 31 femoral anteroposterior length/TPAP, 31 LCAP/TPAP, 30 ATS, 1 ACL cross-sectional area, 32 ACL volume, 32 femoral condylar radius of curvature (FCRC), 2,18,20,31 TPRC, 2,31 FCRC/TPRC, 2,31 meniscal bone angle (MBA), 2,25 MCH, 2,25 MCA, 2,25 and CBH. 2,25 The following parameters were also determined on anteroposterior and lateral knee radiographs: lateral femoral condylar ratio, 13 MTS, 2,7 LTS, 2,7 coronal tibial plateau width (CTPW), 2 and lateral femoral condyle flattening.…”

The correlation between common 2D femoral notch parameters and 3D notch volume: a retrospective MRI study

“…The NWIs at the locations of the femoral notch inlet, outlet, and ACL attachment were not effective parameters for predicting ACL injuries in the multivariate analysis. As the NWI is a ratio that reflects the relative stenosis of the femoral notch and has had numeric cut-off values from 0.19–0.27 in different studies [27–29], its accuracy might be insufficient. Moreover, we suspected that the relative stenosis of the femoral notch in some specific locations might not indicate ACL impingement.…”

Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging

“…The initial changes in osteoarthritis (OA) always occur in the noncalcified part of the articular cartilage (AC), followed by gradual damage to the zone of calcified cartilage (ZCC); however, OA sometimes starts ZCC that could be the subtypes of OA. [ 1 2 ] Therefore, rebuilding the ZCC is an essential strategy in the treatment of OA. The use of bone marrow mesenchymal stem cells (MSCs) to repair the ZCC in some studies represents a new milestone in the treatment of degenerative OA.…”