Narrowband UVB-induced lichen planus pemphigoides

Chan, Wai Man Mandy; Lee, Joyce Siong See; Theng, Colin; Chua, Sze Hon; Oon, Hazel H

doi:10.4081/dr.2011.e43

Cited by 9 publications

(16 citation statements)

References 10 publications

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“…The main adverse reactions were bullous lesion, desquamation and blister formation caused by NBUVB and topical tacrolimus. Studies have reported the bullous pemphigoid induced by PUVA therapy and NBUVB in psoriasis[2122]. Drug interactions were also checked and found five interactions, mainly with PUVASol.…”

Section: Resultsmentioning

confidence: 99%

Myths and facts about vitiligo: An epidemiological study

Abraham¹,

Raghavan²

2015

Indian J Pharm Sci

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Vitiligo is a pigmentary disorder associated with many disease conditions that necessitates multiple drug regimens, which make the treatment complicated. This stigmatic disease forces the patient to approach all system of medicines as well as alternative medicines of non proven value, which further worsens the situation. At the same time the nonadherence to the treatment reflects poor prognosis, which is misunderstood for lack of response resulting in poor faith to the medications. The aim of this work was to assess the patient compliance and the factors affecting, and to monitor the adverse effects as well as drug interactions. The study was carried out in the Institute of Applied Dermatology for a period of one year. Patient compliance was assessed using Morisky Medication Adherence Scale and found that 71% of the patients were low adherent to medications. Family support, faith in doctor, higher educational status and effectiveness of the treatment were some of the reasons for medication adherence whereas forgetfulness, feasibility, occupational problem, polypharmacy, longer duration of treatment and the feeling that the disease under is control were some of the reasons listed for nonadherence. Three adverse reactions were reported with narrow band ultraviolet B and topical tacrolimus therapy and they were categorized into possible and probable according to causality assessment by Naranjo scale. Five drug interactions were reported and the causality assessment was done using drug interaction probability scale. None of the reactions were serious or life threatening. The present study revealed the hurdles in providing safe and effective treatment to the patients and also it suggest the need of doing more research on this disease since there is a general belief that vitiligo is an incurable disease.

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Section: Resultsmentioning

confidence: 99%

Myths and facts about vitiligo: An epidemiological study

Abraham¹,

Raghavan²

2015

Indian J Pharm Sci

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“…In addition, the C-terminal portion of COL17 and desmoglein 1 have been identified as epitopes and antigens, respectively, in LPP (26). Other autoantibodies against unidentified antigens with a molecular weight of 130 kDa (27) and 200 kDa (28) have also been described. The reported variability in autoantigen specificity may result in clinical variants of LPP which appear similar to BP, with autoantibodies against NC16A (24, 29), and MMP with mucosal lesions and autoantibodies against the C-terminal portion of COL17 (26, 30).…”

Section: Etiopathogenesismentioning

confidence: 99%

Lichen Planus Pemphigoides: From Lichenoid Inflammation to Autoantibody-Mediated Blistering

2019

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Lichen planus pemphigoides (LPP) is a very rare autoimmune sub-epidermal blistering disease associated with lichenoid skin changes. Initially thought to be a mere variant of more common inflammatory dermatoses, particularly Bullous Pemphigoid (BP) or Lichen Planus (LP), a growing body of evidence suggests that it is a disease entity in its own right. In common with a range of autoimmune blistering diseases, including BP, pemphigoid gestationis (PG), mucous membrane pemphigoid (MMP) and linear IgA dermatosis (LAD), a key feature of the disease is the development of autoantibodies against type XVII collagen (COL17). However, accurately establishing the diagnosis is dependent on a careful correlation between the clinical, histological and immunological features of the disease. Therefore, we present an up to date summary of the epidemiology and etiopathogenesis of LPP, before illustrating the predisposing and precipitating factors implicated in the development of the disease. In addition to a selective literature search, we compare reports of potential drug-induced cases of LPP with pharmacovigilance data available via OpenVigil. We subsequently outline the cardinal clinical features, important differential diagnoses and current treatment options. We conclude by demonstrating that an improved understanding of LPP may not only lead to the development of novel treatment strategies for the disease itself, but may also shed new light on the pathophysiology of more common and treatment-refractory autoimmune blistering diseases.

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“…Psoralen ultraviolet A (PUVA) [90], narrowband ultraviolet B phototherapy (NBUVB) and photodynamic therapy (PDT) can induce typical and atypical, localized or generalized forms of BP. Rakvit et al reported a case of localized BP induced by PDT [91] and Chan et al reported a case of generalized lichen planus pemphigoides induced by NBUVB therapy [92].…”

Section: Atypical Presentations Of Bullous Pemphigoidmentioning

confidence: 99%