Narrowly dispersed molecularly imprinted microspheres prepared by a modified precipitation polymerization method

Yuan, Jianmin; Jiang, Ming; Shi, Yun; Lin, Yi; Peng, Yan; Dai, Kang; Lü, Bin

doi:10.1016/j.aca.2008.02.011

Cited by 47 publications

(40 citation statements)

References 39 publications

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“…18 Lu et al have used a modied precipitation polymerization method to synthesize microspheres with diameters of about 2-3 mm. 19 The mechanism and inuence factors of this polymerization method were studied. The research on shell thickness for binding capacity, however, is quite limited.…”

Section: -17mentioning

confidence: 99%

Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity

et al. 2014

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Core-shell molecularly imprinted polymers (CS-MIPs) have aroused increasing interest owing to their easy accessibility and favorable mass transfer. Herein, we explore the correlation between shell thickness and binding capacity by using Sudan I as template molecule to prepare different CS-MIPs at the surface of carboxyl polystyrene through emulsion polymerization with a two-step temperature-rising process. Extensive characterization was performed using techniques such as SEM/TEM, FT-IR, BET, and TGA. Main factors were systematically studied such as the amount of prepolymer solution, the amount of SDS, and the temperature step. Under the optimized conditions, CS-MIPs with a shell thickness of 2.60 mm presented the highest binding capacity of 30.1 mmol g À1 and the most rapid mass transfer rate. A uniform sphere model was constructed, and it was found that template molecules located in the spherical MIPs with a diameter of 5.20 mm will be completely eluted, thereby attaining the maximum binding capacity.The static adsorption isotherm followed the Langmuir-Freundlich adsorption model, and the fast kinetics obeyed the pseudo-second-order kinetics model. High recognition specificity for Sudan I with respect to its analogues was displayed, with an imprinting factor of 2.7. The establishment of a critical value of shell thickness provides new insights into the preparation methodology and molecular recognition mechanism of core-shell imprinted polymers.

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Section: -17mentioning

confidence: 99%

Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity

et al. 2014

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“…A very similar approach has been found recently by Jin et al [16] who imprinted different templates using a mixture of toluene with mineral oil or different alkanes as porogenic solvent but gave no explanation on the exciting question: why separate particles form in these porogens instead of the common bulk polymer?…”

Section: Introductionmentioning

confidence: 61%

“…Recently Jin et al have published a so-called , modified precipitation method' that used much less porogen (about 55 wt% of the polymerization mixture) than the conventional precipitation polymerization which uses 90 -98 wt% of solvent [16]. The porogen they used was a mixture of toluene and different alkanes or paraffin oil.…”

Section: Resultsmentioning

confidence: 98%

Preparation of terbutylazine imprinted polymer microspheres using viscous polymerization solvents

Horváth¹,

Lorántfy

Tóth

et al. 2009

J of Separation Science

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Spherical micron sized terbutylazine imprinted polymers have been obtained by copolymerization of acrylates in solvent mixtures containing a highly viscous ('oil') component. The new method requires much less organic solvent than precipitation polymerization to produce spherical MIP particles. Different proportions of oil have been used to clarify its role on the morphology. The particles obtained with the optimal composition could be easily packed into short HPLC columns. Chromatographic retention of the template and other compounds has been determined on the novel ('OMIP') columns and was compared to MIP prepared by bulk polymerization. In 70% aqueous acetonitrile eluent the OMIP shows a higher imprinting factor (i. e. less non-selective binding) and lower retention than the bulk MIP. The chromatographic selectivity against template analogs is similar on OMIP and bulk MIP, while the selectivity against non-related substances is better on the OMIP. The effect of oil on the polymer structure appears to be due to its high viscosity.

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“…One problem is that a large volume of porogen (495%, wt) is necessary during PP, which will also increase the cost and lead to environmental pollution. Jin et al 104 proposed a new method to prepare narrowly dispersed molecularly imprinted microspheres by a modified PP method by using a smaller amount of porogen (about 50 wt%). The modified PP used ultraviolet radiation to initiate the process and used a mixture of mineral oil and toluene as porogen.…”

Section: Precipitation Polymerizationmentioning

confidence: 99%

“…46 Table 1 summarizes MIPs synthesized by PP. 8,46,84,[95][96][97][98][99][100][101][102][103][104][105][106][107][108][109][110][111] To satisfy different application purposes, MIPs with well controlled physical conformations in different size ranges are highly desirable. Many attempts have been made to evaluate the effect of factors upon sizes and shapes of the obtained particles during PP.…”

Section: Precipitation Polymerizationmentioning

confidence: 99%

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

2011

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Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).

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Narrowly dispersed molecularly imprinted microspheres prepared by a modified precipitation polymerization method

Cited by 47 publications

References 39 publications

Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity

Uniform core–shell molecularly imprinted polymers: a correlation study between shell thickness and binding capacity

Preparation of terbutylazine imprinted polymer microspheres using viscous polymerization solvents

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

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