Nasal Acinic Cell Carcinoma in a Cat

Abstract

Abstract. This case report describes the clinical, magnetic resonance imaging (MRI)-related, and pathologic features of a nasal acinic cell carcinoma in a cat. A 16-year-old, castrated male, oriental shorthaired cat, weighing 3.8 kg, was presented with history of sneezing, coughing, and nasal discharge persisting several months. Evaluation by MRI revealed an heterogeneous, space-occupying lesion that filled the left nasal cavity and was diagnosed by histopathologic examination as an acinic cell carcinoma arising from a minor salivary gland of the nasal cavity. Acinic cell carcinoma is a rare tumor in veterinary medicine. The tumor is composed mainly of cells resembling serous cells of salivary glands and originates from major or minor salivary glands. Clinicians and pathologists should be aware of the occurrence of acinic cell carcinoma in the sinonasal tract and include the tumor in the differential diagnosis of feline nasal diseases.

What is your diagnosis? Mandibular mass in a cat

“…The diagnosis is supported by the presence of PAS‐positive diastase‐resistant cytoplasmic secretory granules (consisting of glycoprotein‐based enzymes) in the serous acinar cells, which comprised the bulk of the tumor on histopathologic examination . The positive alcian blue and mucicarmine staining confirmed concurrent differentiation toward mucous acinar cells . Serous cells are infrequently recognized in aspirates of mandibular salivary tissue, because the gland consists of mixed acini with serous demilunes closely associated with the more apparent mucous cells .…”

“…Acinic cell carcinoma can be distinguished from adenocarcinoma by the presence of well‐differentiated acinar salivary gland epithelial cells . The diagnosis is supported by the presence of PAS‐positive diastase‐resistant cytoplasmic secretory granules (consisting of glycoprotein‐based enzymes) in the serous acinar cells, which comprised the bulk of the tumor on histopathologic examination . The positive alcian blue and mucicarmine staining confirmed concurrent differentiation toward mucous acinar cells .…”

“…Most salivary gland tumors are epithelial in origin with adenocarcinoma being the most common tumor type . Acinic cell carcinoma is the second most common salivary gland tumor, arising in the major (usually parotid) or minor salivary glands, including those in the nasal cavity and tongue . Unlike other malignant salivary tumors, acinic cell carcinoma is a low‐grade malignancy characterized by local infiltration with minimal cellular atypia, low mitotic index and rare metastases .…”

“…The acinar cells contained periodic acid‐Schiff (PAS)‐positive diastase‐resistant cytoplasmic granules. The vacuolated cells stained PAS‐positive diastase‐resistant (indicating neutral mucopolysaccharides) and positive for alcian blue and mucicarmine (indicating acid mucopolysaccharides) …”

Paranazal Tümörü Olan İki Kedide Bilgisayarlı Tomografi, Klinik ve Cerrahi Bulguların Değerlendirilmesi

“…The most commonly encountered type of paranasal tumours in the cat are lymphomas [2] . It is a well known fact that most feline nasal and paranasal tumours are malignant [1] .…”