Nasal and ocular responses after specific and nonspecific nasal challenges in seasonal allergic rhinitis

Tomljenovic, Dejan; Baudoin, Tomislav; Megla, Željka Bukovec; Vagić, Davor; Hellings, Peter W.; Kalogjera, Livije

doi:10.1016/j.anai.2015.12.022

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…These findings are in line with previous reports. According to Tomljenovic et al [ 7 ], the VAS score change for eye itching sensation was approximately 1.7 and that in tear production was approximately 2.6 after an allergen challenge. Therefore, we propose using changes in the VAS scores for nasal symptoms, rather than ocular symptoms, after the NPT.…”

Section: Discussionmentioning

confidence: 99%

Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines

Joo

Hyun

Kim

2021

Clin Exp Otorhinolaryngol

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Objectives. We evaluated the usefulness of the standardized nasal provocation test (NPT) protocol recently published by the European Academy of Allergy and Clinical Immunology (EAACI) and compared the utility of several parameters for diagnosing allergic rhinitis (AR) caused by house dust mites (HDM). Subjective parameters were nasal and ocular symptoms measured using a visual analog scale (VAS), and objective parameters were peak nasal inspiratory flow (PNIF), minimal cross-sectional area (MCA), and total nasal volume (TNV). Methods. Before and after spraying Dermatophagoides pteronyssinus (DP) allergen (1,000 AU/mL, 100 μL) into both nostrils of 13 patients with AR (AR group) and 22 patients with non-AR (NAR group), we used VAS scores to measure nasal symptoms (nasal obstruction, rhinorrhea, sneezing, and itching) and ocular symptoms and assessed PNIF, MCA, and TNV. Results. The AR group had significantly worse symptoms than the NAR group 15 minutes after DP challenge (P<0.001). After 30 minutes, nasal obstruction and rhinorrhea remained worse in the AR group (P<0.001); a similar but less marked difference was seen for sneezing (P =0.012) and itching (P =0.039). Ocular symptoms, PNIF, MCA, and TNV differed between groups after both 15 and 30 minutes (P<0.05). The area under the receiver operating characteristic curve was higher for nasal obstruction (0.977), rhinorrhea (0.906), and TNV (0.979) than for sneezing (0.755), itching (0.673), and MCA (0.836). Conclusion. NPT performed according to the EAACI guidelines could help diagnose AR caused by HDM. TNV and VAS changes in nasal obstruction and rhinorrhea had higher diagnostic accuracy than other parameters.

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Section: Discussionmentioning

confidence: 99%

Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines

Joo

Hyun

Kim

2021

Clin Exp Otorhinolaryngol

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“…A mechanistic assessment of the naso-ocular reflex effect on nasal and ocular symptoms after nasal challenges was specifically designed to assess nasal triggers responsible for ocular symptoms, such as pruritus and lacrimation. 17 Ocular and nasal symptoms were assessed before and after nasal allergen and histamine challenges. In addition, participants also recorded their ocular symptoms for the previous 2 pollen seasons.…”

Section: Systemic Allergic and Immune Disordersmentioning

confidence: 99%

The year in review: The best of 2016 in the Annals

Marshall¹,

Bielory²,

Canonica³

et al. 2017

Annals of Allergy, Asthma & Immunology

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“…infections, obstructive anatomic structures), and nonspecific irritants. 10,11 Treatment of AR includes pharmacotherapy, immunotherapy can be considered. 2 Patients with nAR have rhinitis without evidence of infection or allergen sensitization.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical clustering in evaluating inflammatory upper airway phenotypes; increased symptoms in adults with allergic multimorbidity

Hanif

Laulajainen‐Hongisto

Luukkainen

et al. 2020

Asian Pac J Allergy Immunol

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Background: Inflammatory upper airway diseases cause significant morbidity. They include phenotypes with different treatment; allergic or non-allergic rhinitis (AR, nAR), and chronic rhinosinusitis with or without nasal polyps (CRSwNP, CRSsNP). In clinical practice, these phenotypes are often difficult to distinguish and may overlap.Objective: To evaluate if hierarchical clustering can be used to distinguish these phenotypes based on the presence of nasal polyps, off-seasonal allergic symptoms, and self-reported background characteristics -e.g. atopic dermatitis (AD); and to further analyse the obtained clusters. Methods:We studied a random sample of 74 CRS (chronic rhinosinusitis) patients, and a control group of 80 subjects without CRS with/without AR (tertiary hospitals, 2006-2012). All underwent interview and nasal examination, and filled a questionnaire. Variables regarding demographics, off-seasonal symptoms, and clinical findings were collected. Hierarchical clustering was performed, the obtained clusters were cross-tabulated and analysed.Results: Four clusters were identified; 1: "Severe symptoms and CRSwNP" (n = 29), 2: "Asymptomatic AR and controls" (n = 39), 3: "Moderate symptoms and CRSsNP" (n = 36), and 4: "Symptomatic and AD" (n = 50). Cluster 1 had most sinonasal symptoms, cluster 3 had a high prevalence of facial pain. The presence of AR did not distinguish CRS groups. Of the AR subjects, 51 % belonged to cluster 4, where AR with off-seasonal airway symptoms and AD predominated. Conclusion:Hierarchical clustering can be used to distinguish inflammatory upper airway disease phenotypes. The AR phenotype was subdivided by the presence of AD. Adult AR+ AD patients could benefit from active clinical care of the upper airways also off-season.

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Nasal and ocular responses after specific and nonspecific nasal challenges in seasonal allergic rhinitis

Cited by 10 publications

References 16 publications

Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines

Korean Modification of the Nasal Provocation Test With House Dust Mite Antigen Following the EAACI Guidelines

The year in review: The best of 2016 in the Annals

Hierarchical clustering in evaluating inflammatory upper airway phenotypes; increased symptoms in adults with allergic multimorbidity

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