2012
DOI: 10.5487/tr.2012.28.4.217
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Nasal and Pulmonary Toxicity of Titanium Dioxide Nanoparticles in Rats

Abstract: In recent decades, titanium dioxide (TiO2) nanoparticles have been used in various applications, including paints, coatings, and food. However, data are lacking on the toxicological aspects associated with their use. The aim of this study was to assess the inhalation toxicity of TiO2 nanoparticles in rats by using inhalation exposure. Male Wistar rats were exposed to TiO2 nanoparticles for 2 weeks (6 hr/day, 5 days/week) at a mean mass concentration of 11.39 ± 0.31 mg/m3. We performed time-course necropsies at… Show more

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Cited by 28 publications
(19 citation statements)
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“…The repair processes in these experimental studies are not understood well, in part because they have not been studies systematically or consistently. In the study of Kwon et al (2012), temporary histopathological changes in the nasal mucosa resolved by day 15. In another study using a single instillation exposure, pulmonary inflammatory/cytotoxic indices persisted up to 90 days (Skocaj et al, 2011).…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…The repair processes in these experimental studies are not understood well, in part because they have not been studies systematically or consistently. In the study of Kwon et al (2012), temporary histopathological changes in the nasal mucosa resolved by day 15. In another study using a single instillation exposure, pulmonary inflammatory/cytotoxic indices persisted up to 90 days (Skocaj et al, 2011).…”
Section: Discussionmentioning
confidence: 93%
“…Also, TiO 2 nanoparticles inhaled for 2 weeks for 6 h/ day, 5 days/week at the concentration of 11 mg/m 3 led in the rats to histopathological changes in nasal mucosa and the lung tissues (Kwon et al, 2012). Repeated nasal instillation of anatase nanoparticles at a dose of 2.5 mg/kg body weight for 90 days increased the production of MDA in the lung tissues of exposed mice (Li et al, 2013).…”
Section: Discussionmentioning
confidence: 95%
“…A kapott eredmények alátámasztják azt -a humánexpozíció következményei [15] által sejtetett -összefüggést, miszerint a TiO 2 -NP-okkal történő légúti expozíció mind akut, mind krónikus lokális gyulladást hozhat létre a primer célszervben/szövetben. Ennek a -tipikusan foglalkozási -kockázatnak a fennállását modellszámításokkal is igazolták [33].…”
Section: Megbeszélésunclassified
“…Ismert azonban a múltban előfordult munkahelyi TiO 2 -nanopor-terhelésből eredő csökkent légzési kapacitás és pleuramegvastagodás [14]. Állatkísérletben már egyetlen belélegeztetett TiO 2 -NP-dózis a macrophagok aktiválódását [15] és a citokinek fokozott termelését [16] idézte elő. A citokintermelés szoros kapcsolatban áll az autophagiával mint a sejten belülre került idegen anyagok eliminációjának módjával [17] -a bekebelezett NP-ok azonban enzimesen többnyire nem bonthatók le, miáltal a phagosomák normális feldolgozása megakad, továbbá a lysosomák megsérülő membránja hidrolitikus enzimeket, vasat stb.…”
unclassified
“…These toxicities varied depending on the surface properties of nanoparticles [122,123] , chemical composition [119,124] , their half life [125] and distribution [126] . Among the in vivo side effects of nanoparticles, pulmonary inflammation (PSP), pulmonary neoplasia (PSP), immune response (polystyrene, CB, DEP), and platelet aggregations (PM, latex-aggregate surface) are well established [127,128] .…”
Section: Drug Deliverymentioning
confidence: 99%