Nasal capsular cartilage is required for rat transpalatal suture morphogenesis

Nasal Septal and Premaxillary Developmental Integration: Implications for Facial Reduction in Homo

“…Unlike neurocranial sutures, which are regulated via tissue interaction with the dura matter (Opperman et al, 1995;Opperman, 2002), the nasal septal cartilage itself may play an important role in the morphogenesis and regulation of facial sutures (Adab et al, 2002(Adab et al, , 2003. Thus, in addition to passively placing the premaxillary suture under biomechanical strains, thereby promoting osteoblastic and fibroblastic activity (e.g., Rafferty and Herring, 1999;Kopher and Mao, 2002;Mao et al, 2003;Mao, 2006;Katsaros et al, 2006), the nasal septum may also play a more active role in premaxillary suture development.…”

Age-dependent Three-dimensional Microcomputed Tomography Analysis of the Human Midpalatal Suture*

“…Bereits eine veränderte Konsistenz der Nahrung oder die Extraktion von Schneidezähnen führte im Tiermodell zu signifikanten Veränderungen in der Morphologie und im Metabolismus der Sutur [6,22,26]. Anders als bei den Schädelnähten, bei denen über Zellen der Dura mater maßgeblich der Suturenverschluss determiniert wird [9], besitzt der nasale Knorpel die entsprechende Schlüsselrolle für die Gaumennaht [1]. Während der Obliterationsbeginn in den anderen Schädelsuturen als ein kontinuierlich ablaufender Prozess von den Suturenrändern ausgehend beschrieben wurde, ist die Histologie des Obliterationsbeginn bei der Sutura palatina mediana einzigartig [12,40]: Einzelne knöcherne Inseln aus azellulären und irregulär kalzifiziertem Gewebe, welche innerhalb der Sutur liegen oder als kleine Knochenspiculae von den Suturenrändern ausgehen, initiieren in der Sutura palatina mediana den Verknöcherungsprozess.…”

“…As little as a change in the amount of solid food consumed or incisor extractions led in animal studies to significant changes in sutural morphology and metabolism [6,22,26]. As opposed to cranial sutures, where suture closure is clearly determined by dura mater cells [9], nasal cartilage plays the same key role for the palatal suture [1]. While the start of obliteration in other sutures of the skull has been described as a continuous process originating from the suture margins, the histology of the start of obliteration is unique to the midpalatal suture [12,40]: single bony islands of acellular and inconsistently-calcified tissue, located within the suture or protruding as little bone spiculae from the suture margins, initiate the ossification process in the midpalatal suture.…”

Cleft lip and palate genetics and application in early embryological development

“…[8687] As in cranio-facial sutures, the MP and trans-palatal (TP) suture osteoblasts express Tgfβ1, 2 and 3, while the suture cells express primarily Tgfβ3. [8889]…”

“…[90] The MP and TP sutures have different morphology, so they are not in contact with the dura mater. Opperman's group hypothesized that these facial sutures are growth centres[8889] and that the nasal capsular cartilage produces signalling molecules to regulate the fusion of MP and TP sutures [Figure 3]. [89] They found that the nasal cartilage maintained the TP sutures as growth sites in experiments on rat palatal organ cultures (E20) with or without nasal cartilage.…”