Nasal cartilage tissue engineering materials based on 3D bioprinting: Seed cells and dECM

Jia, Wendan; Yang, Xiaoning; Liu, Zixian; Sun, Lei; Shen, Zhizhong; Li, Meng; Zhang, Hulin; An, Yang; Sang, Shengbo

doi:10.1016/j.apmt.2024.102364

Applied Materials Today

2024

DOI: 10.1016/j.apmt.2024.102364

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Nasal cartilage tissue engineering materials based on 3D bioprinting: Seed cells and dECM

Wendan Jia,

Xiaoning Yang,

Zixian Liu

et al.

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2024

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Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for Cartilage Tissue Engineering Applications

Boretti,

Baldursson,

Buonarrivo

et al. 2024

Polymers

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Articular cartilage degeneration poses a significant public health challenge; techniques such as 3D bioprinting are being explored for its regeneration in vitro. Gelatin-based hydrogels represent one of the most promising biopolymers used in cartilage tissue engineering, especially for its collagen composition and tunable mechanical properties. However, there are no standard protocols that define process parameters such as the crosslinking method to apply. To this aim, a reproducible study was conducted for exploring the influence of different crosslinking methods on 3D bioprinted gelatin structures. This study assessed mechanical properties and cell viability in relation to various crosslinking techniques, revealing promising results particularly for dual (photo + ionic) crosslinking methods, which achieved high cell viability and tunable stiffness. These findings offer new insights into the effects of crosslinking methods on 3D bioprinted gelatin for cartilage applications. For example, ionic and photo-crosslinking methods provide softer materials, with photo-crosslinking supporting cell stretching and diffusion, while ionic crosslinking preserves a spherical stem cell morphology. On the other hand, dual crosslinking provides a stiffer, optimized solution for creating stable cartilage-like constructs. The results of this study offer a new perspective on the standardization of gelatin for cartilage bioprinting, bridging the gap between research and clinical applications.

show abstract

Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for Cartilage Tissue Engineering Applications

Boretti,

Baldursson,

Buonarrivo

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

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Nasal cartilage tissue engineering materials based on 3D bioprinting: Seed cells and dECM

Cited by 1 publication

References 119 publications

Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for Cartilage Tissue Engineering Applications

Mechanical and Biological Characterization of Ionic and Photo-Crosslinking Effects on Gelatin-Based Hydrogel for Cartilage Tissue Engineering Applications

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