Nasal challenge with allergen leads to maxillary sinus inflammation

Baroody, Fuad M.; Mucha, Samantha M.; deTineo, Marcy; Naclerio, Robert M.

doi:10.1016/j.jaci.2008.02.010

Cited by 88 publications

(67 citation statements)

References 30 publications

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“…Eosinophil numbers significantly increased not only in the ipsilateral but, to an equivalent extent, also in the contralateral maxillary sinuses. 37 These findings show the systemic nature of allergic inflammatory responses and a viable mechanism whereby inhalant aeroallergen exposure in the nares could drive CHES.…”

Section: Figure 1 Overview Of the Mechanism By Which Allergen Immunementioning

confidence: 86%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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Section: Figure 1 Overview Of the Mechanism By Which Allergen Immunementioning

confidence: 86%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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“…On a pathologic basis, nasal challenge with allergens in allergic individuals leads to an influx of eosinophils into the maxillary sinus. 115 Similarly, the majority of subjects with ragweed-sensitive AR (60%) had sinus mucosal abnormalities on CT imaging during the peak of ragweed season, yet resolution of symptoms after treatment did not correlate with radiologic imaging. 116 Furthermore, individuals with ragweed AR had significantly more eosinophils in the maxillary sinus during the ragweed season compared to outside the ragweed season.…”

Section: Vb Ars: Pathophysiologymentioning

confidence: 96%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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559

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…Stagnation of secretions, decreased ventilation, mucosal inflammation and decreased mucociliary transport all contribute to facilitate bacterial infection (6). Besides, recent works have shown that nasal challenge with allergen causes also secondary maxillary sinus inflammatory response in addition to nasal inflammatory changes (13). These findings might help explain the close relationship between allergic rhinitis and rhinosinusitis, two very common diseases that frequently coexist.…”

Section: Epidemiologic Levelmentioning

confidence: 84%

Rhinosinusitis and Asthma: A Very Long Engagement

Licari

Caimmi

Bosa

et al. 2014

Int J Immunopathol Pharmacol

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Upper and lower airways may be considered as a unique entity, interested by coexisting inflammatory processes that share common etiopathogenic mechanisms. Previous studies have strongly demonstrated a relationship between rhinosinusitis and asthma. This has led to the introduction of the concept of “united airways”, which has also been included in the WHO document Allergic Rhinitis and its Impact on Asthma (ARIA); this concept has important consequences also on the treatment of these disorders. To better summarize the evident connection between upper and lower airway disease we decided to describe it as a multilayered construction, each level pointing out more deeply the relationship between these entities.

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Nasal challenge with allergen leads to maxillary sinus inflammation

Cited by 88 publications

References 30 publications

Chronic sinusitis pathophysiology: The role of allergy

Chronic sinusitis pathophysiology: The role of allergy

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Rhinosinusitis and Asthma: A Very Long Engagement

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