Nasal chondromesenchymal hamartoma in an adolescent

Low, Su Enn; Sethi, RK; Davies, Elgan; Stafford, Jeremy

doi:10.1111/j.1365-2559.2006.02431.x

Cited by 13 publications

(9 citation statements)

References 5 publications

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“…1,3,6e10,22e26 The aetiopathogenesis of both NCMH and SFOH is obscure, but authors have suggested the possibility of a congenital disease 6 ; in the few cases reported in adults a proper hormonal or environmental stimulus could have led the lesion present since birth to grow. 9,22,23,25 In cats, the early age of diagnosis (usually between 6 and 12 months) suggests the possibility of a hereditary or congenital cause. In support of a genetic predisposition, IPNT have been diagnosed in brothers and in a kitten related to a previously affected male cat.…”

Section: Discussionmentioning

confidence: 99%

“…6,7,9,10,22,25 The presence of inflammatory cells has been seldom reported. 6,9,23 Cases of NCMH lacking a cartilage component have been reported and the need for cartilage as a prerequisite for the diagnosis of NCMH requires further evaluation. 8,30 Reported cases of IPNT in cats have shown the entire collage of NCMH, but in cats the predominant component is bone rather than cartilage.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Polyps of the Nasal turbinates of cats: An argument for designation as feline mesenchymal nasal hamartoma

Greci

Mortellaro

Olivero³

et al. 2011

Journal of Feline Medicine and Surgery

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Inflammatory polyps of the nasal turbinates (IPNT) in cats are benign growths that are histologically distinct from feline nasopharyngeal polyps. Most cats with IPNT are presented at less than 1 year of age with sneezing, noisy breathing and epistaxis, but without mucoid or mucopurulent nasal discharge. Histologically, IPNT are characterised by the presence of woven bone as part of the proliferating stroma and erythrocyte-filled spaces. These unique histological features are analogous to nasal hamartomas (NH) of children, specifically chondromesenchymal hamartoma (NCMH) and sinonasal fibro-osseous hamartoma (SFOH), which also result in signs of nasal obstruction, sneezing and epistaxis. In our study, clinical and histopathological features in five cats with IPNT were compared with published descriptions of NH in children. We conclude that the terminology 'feline mesenchymal nasal hamartoma' provides a more accurate description of the disease currently termed IPNT, and has the added advantage of being consistent with its human counterpart.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inflammatory Polyps of the Nasal turbinates of cats: An argument for designation as feline mesenchymal nasal hamartoma

Greci

Mortellaro

Olivero³

et al. 2011

Journal of Feline Medicine and Surgery

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“…The NCMH were diagnosed at ages 7-15 years, from 4 to 12 years after the child's PPB diagnosis. In 24 NCMH not associated with PPB, ages at diagnosis were birth to 69 years, median 8 months, with seven cases between ages 11 and 25 years [1][2][3][4][5][6][7][8][9][10][11][12][13][14]16,21]. The anatomic extent of PPB-associated NCMH (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-six NCMH cases have previously been reported, predominantly in infants [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. NCMH has a mixed morphologic composition of immature cartilage surrounded by spindle cell stroma with or without fibro-osseous and aneurysmal bone cystlike features [1].…”

Section: Introductionmentioning

confidence: 99%

Nasal chondromesenchymal hamartoma in children with pleuropulmonary blastoma—A report from the International Pleuropulmonary Blastoma Registry registry

Priest¹,

Williams²,

Mize³

et al. 2010

International Journal of Pediatric Otorhinolaryngology

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“…Nasal cavity ND None stated ND Surgical excision ND 2. Ethmoid sinus (11) Low 2006 [ 33 ] UK 21 11 Y M Right Size: ND 1. Nasal cavity 1.…”

Section: Methodsmentioning

confidence: 99%

Nasal Chondromesenchymal Hamartoma (NCMH): A systematic review of the literature with a new case report

Mason

Navaratnam

Theodorakopoulou

et al. 2015

Journal of Otolaryngology - Head & Neck Surgery

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BackgroundNasal chondromesenchymal hamartoma (NCMH) is a very rare, benign tumour of the sinonasal tract usually presenting in infants. We present a systematic review of NCMH cases alongside a case report of an adult with asymptomatic NCMH.MethodsA systematic review was conducted in accordance with PRISMA guidelines. A PubMed, EMBASE and manual search through references of relevant publications was used to identify all published case-reports of NCMH. Data was collected from each case-report on: patient demographics, laterality, size and location of NCMH, presentation, co-morbidities, investigations, treatment and follow-up.ResultsThe systematic review identified 48 patients (including ours): 33 male, 15 female. Mean age was 9.6 years (range: 1 day–69 years) with the majority aged 1 year or younger at presentation (n = 18). Presentations included: nasal congestion (n = 17), nasal mass (n = 15) and eye signs (n = 12). NCMH also involved the paranasal sinuses (n = 26), orbit (n = 16) and skull-base (n = 14). All patients underwent operative resection of NCMH. A small 2014 case-series found DICER1 mutations in 6 NCMH patients, establishing a link to the DICER1 tumour spectrum.ConclusionsNCMH is a rare cause of nasal masses in young children and adults. In light of the newly established link between NCMH and DICER1 mutations surgeons should be vigilant for associated DICER1 tumours, as NCMH may be the ‘herald tumour’ of this disease spectrum.

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Nasal chondromesenchymal hamartoma in an adolescent

Cited by 13 publications

References 5 publications

Inflammatory Polyps of the Nasal turbinates of cats: An argument for designation as feline mesenchymal nasal hamartoma

Inflammatory Polyps of the Nasal turbinates of cats: An argument for designation as feline mesenchymal nasal hamartoma

Nasal chondromesenchymal hamartoma in children with pleuropulmonary blastoma—A report from the International Pleuropulmonary Blastoma Registry registry

Nasal Chondromesenchymal Hamartoma (NCMH): A systematic review of the literature with a new case report

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