Nasal Ciliated Epithelium, with Special Reference to Infection and Treatment

Proetz, Arthur W.

doi:10.1017/s0022215100040585

Cited by 44 publications

(7 citation statements)

References 12 publications

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“…6 Similar wave-like movements have been well described by Proetz (17,25,27) and illustrated by him with motion pictures. after recovery from anesthesia with choral hydrate showed strong activity.…”

Section: Effect Of Anesthesia With Chloral 11ydrate--since Intrabronsupporting

confidence: 55%

“…Wave-like movements have been accepted by numerous workers as visible manifestations of ciliary beat (23)(24)(25)(26)(27)(28)17) and have frequently been used as a test of whether application of drugs to respiratory epithelia does harm to the ciliary mechanism. In view of this general opinion, it is necessary to realize that such movements, as observed in the bronchus of the mouse, were not found to be due to cilia.…”

Section: Discussionmentioning

confidence: 99%

“…In order to ascertain the effect of viral infection on broncial cilia, it was necessary to have a method for evaluation of ciliary action. A technique frequently used for this purpose consists of the visualization of wave-like movements on the surface of respiratory epithelium (23)(24)(25)(26)(27)(28)17), and adaptation of this method to the bronchus of the mouse was readily made.…”

Section: Wave-like Movements Of the Bronch~ ~mentioning

confidence: 99%

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Effect of Influenza Virus on Cilia and Epithelial Cells in the Bronchi of Mice

Harford¹,

Hamlin²

1952

Journal of Experimental Medicine

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A study of bronchial cilia in mice was carried out in order to obtain evidence as to how influenza viral infection of the mouse lung lowers rcsistancc to secondary pneumococcal pneumonia. Earlier work had shown that this effect is associated with the viral lesion rather than the presence of the virus per se and had suggested that viral infection damages antibacterial mechanisms of the lung (I). Particular attention was given to cilia because of the histologic evidence that influenza viral infection of the mouse causes necrosis of the bronchial epithelium (I-8). In addition, it has bccn shown that ciliary action removes foreign particles from the respiratory passages and therefore probably serves as an important mechanism of nativc resistance to bacterial infection of the respiratory tract (9-20). I When severe infection with influenza virus was induced in mice, it was found that active ciliary beat persisted in the bronchi of involved lungs and that cilia could be shown to be present in stained sections of the viral lesion. = These findings were unexpected because it was thought that this viral infection causes destruction of bronchial epithelial cells. For this reason, further experiments were done to clarify the nature of the viral lesion. The result of this investigation has revealed no evidence that actual destruction of the epithelium takes place. Instead of nuclear changes in the early viral lesion, basophilic intracytoplasmic inclusion bodies have bccn found. Evidence has also been obtained to indicate that portions of the cytoplasm of non-ciliated cells become detached and are shed into the lumen. EXPERIMENTAL METHODS AND RESULTS Wave-Like Movements of the Bronch~ ~In order to ascertain the effect of viral infection on broncial cilia, it was necessary to have a method for evaluation of ciliary action. A technique frequently

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Section: Effect Of Anesthesia With Chloral 11ydrate--since Intrabronsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Wave-like Movements Of the Bronch~ ~mentioning

confidence: 99%

See 1 more Smart Citation

Effect of Influenza Virus on Cilia and Epithelial Cells in the Bronchi of Mice

Harford¹,

Hamlin²

1952

Journal of Experimental Medicine

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“…Statements regarding the number of central fibrils have varied, figures up to 12 double fibrils having been given (Randall and Friedlaender). The caliber has been found to vary in different types of fibrils.…”

Section: Structure Of Some Different Forms Of Ciliamentioning

confidence: 99%

LXXX Some Principles in the Structure of Vibratile Cilia

Engström¹,

Wersäll²

1952

Ann Otol Rhinol Laryngol

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“…12 Cilia slow immediately, and cease to beat in a very short time if they are not kept moist and recover their activity only after a considerable period of moistening. Proetz11 showed that cilia beat effectively at between 18 and 33 degrees C. He observed the cilia both in living rabbits' sinuses and also in extirpated human membranes and writes: "At 35 degrees C. it became necessary to supply fluids with increasing frequency owing to evaporation.…”

Section: No4mentioning

confidence: 99%

LXXI Intranasal Vaccine Spray: Its Use in Prophylaxis against the Common Cold

Walsh¹

1940

Ann Otol Rhinol Laryngol

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Nasal Ciliated Epithelium, with Special Reference to Infection and Treatment

Cited by 44 publications

References 12 publications

Effect of Influenza Virus on Cilia and Epithelial Cells in the Bronchi of Mice

Effect of Influenza Virus on Cilia and Epithelial Cells in the Bronchi of Mice

LXXX Some Principles in the Structure of Vibratile Cilia

LXXI Intranasal Vaccine Spray: Its Use in Prophylaxis against the Common Cold

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