Nasal colonization with methicillin-resistant Staphylococcus aureus: Clinical implications and treatment

Friedel, David; Climo, Michael W.

doi:10.1007/s11908-007-0032-1

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…aureus may lead to a higher probability of developing infections. Indeed, it has been previously shown that in approximately 65% of the cases, genetic similarity between the colonizing and invasive strains can be demonstrated [ 3 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus USA300 Latin American Variant in Patients Undergoing Hemodialysis and HIV Infected in a Hospital in Bogotá, Colombia

et al. 2015

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We aimed to determine the prevalence of MRSA colonization and examine the molecular characteristics of colonizing isolates in patients receiving hemodialysis and HIV-infected in a Colombian hospital. Patients on hemodialysis and HIV-infected were prospectively followed between July 2011 and June 2012 in Bogota, Colombia. Nasal and axillary swabs were obtained and cultured. Colonizing S. aureus isolates were identified by standard and molecular techniques. Molecular typing was performed by using pulse-field gel electrophoresis and evaluating the presence of lukF-PV/lukS-PV by PCR. A total of 29% (n = 82) of HIV-infected and 45.5% (n = 15) of patients on hemodialysis exhibited S. aureus colonization. MSSA/MRSA colonization was observed in 28% and 3.6% of the HIV patients, respectively and in 42.4% and 13.3% of the hemodialysis patients, respectively. Staphylococcal cassette chromosome mec typing showed that four MRSA isolates harbored the type IV cassette, and one type I. In the hemodialysis group, two MRSA isolates were classified as belonging to the USA300-LV genetic lineage. Conversely, in the HIV infected group, no colonizing isolates belonging to the USA300-Latin American Variant (UDA300-LV) lineage were identified. Colonizing isolates recovered from the HIV-infected group belonged to the prevalent hospital-associated clones circulating in Latin America (Chilean [n = 1] and Pediatric [n = 2]). The prevalence of MRSA colonization in the study groups was 3.6% (HIV) and 13.3% (hemodialysis). Surveillance programs should be implemented in this group of patients in order to understand the dynamics of colonization and infection in high-risk patients.

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Section: Discussionmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus USA300 Latin American Variant in Patients Undergoing Hemodialysis and HIV Infected in a Hospital in Bogotá, Colombia

et al. 2015

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“…Aerosolized vancomycin has been shown to eliminate tracheal MRSA colonization, although it carries a risk of bronchospasm 44. This practice has been discouraged by the United States Centers for Disease Control and Prevention (CDC) due to the potential for inadvertent ingestion of antibiotics and the subsequent selection of vancomycin‐resistant enterococci 45, 46. Some authors have advocated the addition of a topical skin disinfectant for long‐term eradication,43 arguing that failure to prevent recolonization with MRSA may indicate the presence of extranasal colonization at sites such as the perineum or axilla.…”

Section: Discussionmentioning

confidence: 99%