Nasal decontamination for the prevention of surgical site infection in<i>Staphylococcus aureus</i>carriers

Liu, Zhenmi; Norman, Gill; Iheozor‐Ejiofor, Zipporah; Wong, Jason; Crosbie, Emma J.; Wilson, Peter

doi:10.1002/14651858.cd012462

Cited by 9 publications

(11 citation statements)

References 37 publications

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“…Nasal colonization with S. aureus has been identified as a significant risk factor for surgical site infection (3,4), but the prevalence of nasal colonization in patients with RA, and the factors that increase the risk of S. aureus colonization in patients with RA are not well established. In the general population, the prevalence of S. aureus colonization has been reported at 30% (5).…”

Section: Introductionmentioning

confidence: 99%

Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy

Goodman

Nocon

Selemon

et al. 2019

The Journal of Arthroplasty

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Background: Rheumatoid arthritis patients are at increased risk for periprosthetic joint infection after arthroplasty. The reason is multifactorial. Nasal colonization with Staphylococcus aureus is a modifiable risk factor; carriage rates in RA patients is unknown. The goal of this study was to determine the S. aureus nasal carriage rates of RA patients on biologics, RA patients on traditional DMARDs, and osteoarthritis. Methods: Consecutive patients with RA on biologics (+/− DMARDs), RA on non-biologic DMARDs, or OA were prospectively enrolled from April 2017 to May 2018 123 patients were determined necessary per group to show a difference in carriage rates. Patients underwent a nasal swab and answered questions to identify additional risk factors. S. aureus positive swabs were further categorized using Spa typing. Logistic regression evaluated the association with S. aureus colonization between the groups after controlling for known risk factors. Results: RA patients on biologics, 70% of whom were on DMARDs, had statistically significant increase in S. aureus colonization (37%) compared to RA on DMARDs alone (24%), or OA (20%) p = 0.01 overall. After controlling for glucocorticoids, antibiotic use, recent hospitalization, and diabetes, RA on biologics had a significant increased risk of S. aureus nasal colonization (OR=1.80, 95% CI 1.00-3.22); p=0.047). Conclusion: S. aureus colonization risk was increased for RA on biologics compared to RA not on biologics and OA. Nasal S. aureus carriage increases the risk of surgical site infection; this

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Section: Introductionmentioning

confidence: 99%

Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy

Goodman

Nocon

Selemon

et al. 2019

The Journal of Arthroplasty

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“…This prevalence in our study agreed with the foreign literature, where it ranges from 1.5 to 5.9%. 9,20,21,28 None of our patients had infections of the surgical wound.…”

Section: Discussionmentioning

confidence: 75%

“…The most common reservoir site for S. aureus is the nostrils, followed by the groin, armpits, and perianal region. 5 We used a swab of the nostrils as the screening method, since it is the most widely used in the literature, [19][20][21] has greater sensitivity, and does not embarrass the patients. This swab can be submitted to two types of analysis to identify MRSA: the polymerase chain reaction (PCR) and seeding microbiological culture medium.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Methicillin-Resistant Staphylococcus Aureus in Spinal Surgery Patients

et al. 2019

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Objective The objective of this study was to determine the prevalence of patients with colonization of methicillin-resistant Staphylococcus aureus (MRSA) in the nasal mucosa, who underwent elective spinal procedures. Methods Retrospective study of the medical records of all patients submitted to elective procedures, totaling 125 individuals in the period of 2015 and 2017, performed by two spinal surgeons of the Orthopedics and Traumatology Service of Hospital Mater Dei, Belo Horizonte, Minas Gerais. The pre-operative investigation of MRSA consisted of the collection of a nasal swab for microbiological culture. Results Of the 125 patients evaluated, three (2.4%) showed positive results for MRSA nasal colonization. This prevalence is consistent with the international literature, that ranges from 1.5 to 5.9%. Of these patients none had infection of the surgical wound, probably due to the preoperative prophylactic measures. Conclusions Despite the limitations of the study, we found that the prevalence of carriers of this nasal MRSA population is similar to that of populations worldwide . Level of evidence III; Retrospective Study.

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“…Ein Cochrane‐Review resümiert allerdings, dass die nasale Dekontamination bei S. aureus allein (ohne Kombination mit antiseptischer Waschung) zu keiner sicheren Reduktion der SSI‐Raten mit S. aureus führt 17 .…”

Section: Präoperative Dekolonisierungunclassified

Möglichkeiten und Grenzen der präoperativen Dekolonisierung

Sasse¹,

Wendt²,

Lübbert³

2022

Orthopädie und Unfallchirurgie up2date

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Nasal decontamination for the prevention of surgical site infection inStaphylococcus aureuscarriers

Abstract: Nasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers.

Cited by 9 publications

References 37 publications

Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy

Increased Staphylococcus aureus Nasal Carriage Rates in Rheumatoid Arthritis Patients on Biologic Therapy

Prevalence of Methicillin-Resistant Staphylococcus Aureus in Spinal Surgery Patients

Möglichkeiten und Grenzen der präoperativen Dekolonisierung

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