Nasal Delivery of [14C]Dextromethorphan Hydrochloride in Rats: Levels in Plasma and Brain

Charx, Hing; Kumar, Saran; Patel, Saumya; Piemontese, David; Iqbal, Khurshid; Malick, A. Waseem; Salvador, Richard A.; Behl, Christian

doi:10.1002/jps.2600810806

Cited by 31 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was also concluded that intranasal delivery of hydrophilic drug to brain is practical. Char H et al [93] have evaluated the potential of intranasal delivery of [14C] dextromethorphan hydrochloride (DM) in rat brain. The study revealed uptake of DM in brain following intranasal route was 65.9% when compared to intravenous route.…”

Section: Delivery Of Non-peptide Molecules To the Cnsmentioning

confidence: 99%

Intranasal Drug Delivery for Brain Targeting

Vyas¹,

Shahiwala²,

Marathe³

et al. 2005

CDD

221

View full text Add to dashboard Cite

Many drugs are not being effectively and efficiently delivered using conventional drug delivery approach to brain or central nervous system (CNS) due to its complexity. The brain and the central nervous system both have limited accessibility to blood compartment due to a number of barriers. Many advanced and effective approaches to brain delivery of drugs have emerged in recent years. Intranasal drug delivery is one of the focused delivery options for brain targeting, as the brain and nose compartments are connected to each other via the olfactory route and via peripheral circulation. Realization of nose to brain transport and the therapeutic viability of this route can be traced from the ancient times and has been investigated for rapid and effective transport in the last two decades. Various models have been designed and studied by scientists to establish the qualitative and quantitative transport through nasal mucosa to brain. The development of nasal drug products for brain targeting is still faced with enormous challenges. A better understanding in terms of properties of the drug candidate, nose to brain transport mechanism, and transport to and within the brain is of utmost importance. This review will discuss some pertinent issues to be considered and challenges to brain targeted intranasal drug delivery. A few marketed and investigational drug formulations will also be discussed.

show abstract

Section: Delivery Of Non-peptide Molecules To the Cnsmentioning

confidence: 99%

Intranasal Drug Delivery for Brain Targeting

Vyas¹,

Shahiwala²,

Marathe³

et al. 2005

CDD

221

View full text Add to dashboard Cite

show abstract

“…Similarly, the nasal route has been shown to be a viable alternative in animals, with drug absorption following IV profiles. 112 Nevertheless, oral administration remains the most convenient, particularly for potential treatment of chronic neurologic disorders. The most promising strategy for increasing systemically available DM, therefore, seems to be the coadministration of the specific and reversible CYP2D6 inhibitor, quinidine (Q).…”

Section: Enhancing Central Bioavailability Of Dm As a Neuroprotectivementioning

confidence: 99%

Dextromethorphan as a Potential Neuroprotective Agent With Unique Mechanisms of Action

Werling¹,

Lauterbach²,

Calef³

2007

The Neurologist

View full text Add to dashboard Cite

show abstract

“…Overall, mean concentrations of DM in the spinal cord were approximately 57% higher than those observed in the brain. Although previous studies have characterized the pharmacokinetic of DM in the brain of rats (Char et al, 1992;Wu et al, 1995), this is the first study to present the pharmacokinetic behavior of DM in the spinal cord of rat. The higher availability of DM in the spinal cord may be associated to a higher penetrability in this region of the CNS since the intercellular junctions in the spinal cord are not as tight as those found in the brain (Sugawara et al, 1990).…”

Section: Discussionmentioning

confidence: 94%