Nasal delivery systems and their effect on deposition and absorption

Kublik, H.; Vidgrén, M.

doi:10.1016/s0169-409x(97)00067-7

Cited by 202 publications

(80 citation statements)

References 43 publications

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“…Other contributory mechanisms are gravitational sedimentation and Brownian diffusion. Particle deposition by interception and electrostatic precipitation are of no importance in nasal deposition (Kublik & Vidgren 1998). Depending on the type of formulation, a variety of devices have been used to give drugs intranasally but mostly in experimental studies.…”

Section: Factors That Influence Nasal Drug Absorptionmentioning

confidence: 99%

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Ugwoke

Verbeke

Kinget

2001

Journal of Pharmacy and Pharmacology

301

158

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Nasal drug administration has frequently been proposed as the most feasible alternative to parenteral injections. This is due to the high permeability of the nasal epithelium, allowing a higher molecular mass cut-off at approximately 1000 Da, and the rapid drug absorption rate with plasma drug profiles sometimes almost identical to those from intravenous injections.Despite the potential of nasal drug delivery, it has a number of limitations. In this review, the anatomy and physiology of the nasal cavity, as well as ciliary beating and mucociliary clearance as they relate to nasal drug absorption, are introduced. The rationale for nasal drug delivery and its limitations, some factors that influence nasal drug absorption, and the experimental models used in nasal drug delivery research are also reviewed. Nasal mucoadhesion as a promising method of nasal absorption enhancement is discussed, and factors that influence mucoadhesion, as well as safety of nasal mucoadhesive drug delivery systems are reviewed in detail.Nasal drug administration is presently mostly used for local therapies within the nasal cavity.

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Section: Factors That Influence Nasal Drug Absorptionmentioning

confidence: 99%

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Ugwoke

Verbeke

Kinget

2001

Journal of Pharmacy and Pharmacology

301

158

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“…For example the use of suspension, ointments, powders, has been reported to increase the contact time within the mucosa in comparison to solution. [28] Nasal drops are one of the most straightforward and convenient systems developed for nasal delivery. The main disadvantage of this method is that the lack of the dose preciseness and so nasal drops might not be appropriate for prescription products.…”

Section: Nasal Formulationsmentioning

confidence: 99%

Nasal Drug Delivery System: A Route for Braine Targetting

Jadhav¹

2017

WJPR

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Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain.Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of medication in the remaining tissues. Thus improving efficacy of the drug and reducing side effects. The nasal mucosa when compared to other mucous membranes is easily accessible and provides a practical entrance portal for small and large molecules. Intranasal administration offers rapid onset of action, no first-pass effect, no gastrointestinal degradation or lung toxicity and non-invasiveness application and also improves bioavailability. It is thought that olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field.

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“…Nasal formulations include gels, liquids, powdered particulates and pressurised metered dose inhalers [149] with powder and pressurised metered dose inhalers being the most common. Commercially available formulations for nasal delivery have been achieved using pectin polysaccharide for the delivery of fentanyl [150].…”

Section: Polysaccharide-based Nasal Delivery Systemsmentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

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There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

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Nasal delivery systems and their effect on deposition and absorption

Cited by 202 publications

References 43 publications

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

The biopharmaceutical aspects of nasal mucoadhesive drug delivery

Nasal Drug Delivery System: A Route for Braine Targetting

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

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