Nasal glioma in an infant

Prenatal diagnosis of a nasal glioma in the mid trimester

“…Abnormal closure of the anterior fontanel between the nasal and frontal bones during embryonic development can cause incomplete separation of ectodermal and neuroectodermal elements. Nasal glioma may develop if neuroglial tissue remnants persist extracranially following closure of the anterior fontanel, while anterior encephaloceles are due to the herniation of the meninges (with or without brain tissue) through an improperly closed fontanel2.…”

Conditions masquerading as infantile haemangioma: Part 2

“…If nasal glioma is a diagnostic consideration, imaging studies such as MR or CT should be undertaken both for diagnostic purposes and to exclude intracranial extension, estimated to occur in up to 25% of cases. [29][30][31] Histopathology can easily distinguish between the two conditions, as neuroglial tissue rather than endothelial cells are identified, and this can be confirmed with special stains such as S100, glial fibrillary acid protein and neuronspecific enolase. [29][30][31] …”

“…7). 24,[29][30][31] Those with presentation as a congenital soft-tissue mass can be more easily distinguished, but some nasal gliomas continue to grow, leading to further diagnostic confusion. Those involving the nasal bridge or tip can be particularly hard to diagnose, as these are common locations for IH.…”

“…Nasal gliomas have often been mistaken for IH, likely due to the similar location and appearance. 24,[29][30][31] . Nasal gliomas may be extranasal (60%), intranasal (30%) or combined (10%).…”

Select the most correct answers – multiple answers possible for questions 1–11

“…Nasal gliomas have often been mistaken for IH, likely due to the similar location and appearance. 24,[29][30][31] . Nasal gliomas may be extranasal (60%), intranasal (30%) or com-bined (10%).…”