Nasal Glioma (Neuroglial Heterotopia) Mimicking an Astrocytoma: Case Report

Abstract

Nasal glioma is a rare benign tumor that usually occurs during infancy. We report a case of nasal glioma in a 6-month-old boy in which the histomorphologic features resembled those of an anaplastic astrocytoma.

Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review

“…This includes all cases involving the nasopharynx, oropharynx, or parapharyngeal space. Of these, 12 cases were localized to the nasopharynx, and all manifested as neonatal airway obstruction [1,2,4,5,10,16,[18][19][20][21]25].…”

“…While most commonly found in the nasal cavity, heterotopic neuroglial tissue has been found in the scalp, orbit, middle ear, pharynx, palate, tongue, and neck [5,13]. Approximately 12 cases of neuroglial heterotopias in the nasopharynx have been reported in the English literature [1,2,4,5,10,16,[18][19][20][21]25]. A case is discussed of neuroglial heterotopia in the nasopharynx manifesting as airway obstruction in the newborn.…”

Nasal glial heterotopia: a systematic review of the literature and case report

“…These incidence rates differ from those reported by Yan et al who described a 5% recurrence during a follow-up from 0.5 to 3 years 4 . This difference may be attributable to the relatively small sample size (60 patients) of the study by Yan et al Previous reviews reported the lack of recurrence or tumour-invasion into adjacent tissues during long-term follow-up 19 . Schroth et al 20 described a regrowth of an intra-nasal NGH mass just 5 weeks after primary excision, which was more infiltrating than the initial tumour which required a much more mutilating excision including nasal cartilages, upper nasal septum and parts of the nasal bone, as well as a posterior reconstruction of the nose with autologous skin and ear cartilage transplants to correct the defects.…”

Nasal glial heterotopia: Clinical and morphological characteristics

“…а -позитивное окрашивание матрикса и клеток астроцитарной глии антителами к виментину; б -позитивное окрашивание матрикса и клеток астроцитарной глии антителами к S100-протеину; в -цитоплазматическая экспрессия нейронспецифической энолазы в клетке с нейрональной дифференцировкой; г -экспрессия гладкомышечного актина клетками астроцитарной глии; д -экспрессия гладкомышечного актина клетками с нейрональной дифференцировкой; е -цитоплазматическая экспрессия гладкомышечного актина в ганглиозных клетках; а, б -иммунопероксидазный метод, ×200; в-е -иммунопероксидазный метод, ×400. с растущим ребенком [8]. В литературе встречается описание двусторонней НГГ в сочетании с астроцитомой одного из полушарий головного мозга [9], где авторы так и не пришли к окончательному решению, считать ли экстракраниальные образования астроцитомами или параллель-но существующими мальформациями вне связи с астроцитомой головного мозга.…”