Nasal Inflammatory Mediators In Non-steroidal Anti-inflammatory Drugs (nsaids) Cross-intolerant Subjects After Lysine Nasal Challenge

Doña, Inmaculada; Campo, Paloma; Sanak, Marek; Cornejo, Jose Antonio; Corrêa, Anna Carolina Nitzsche Teixeira Fernandes; Blanca‐López, Natalia; Salas, María; Sanchez, Maritza; Cantó, Gabriela; Blanca, Miguel

doi:10.1016/j.jaci.2011.12.758

Cited by 1 publication

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“…When this analysis was repeated after stratification of these patients into MNSAID‐UA and AERD, house dust mites were the main allergens in MNSAID‐UA patients and grass allergens in AERD patients. Nevertheless, further research is needed to clarify the role of atopy in NSAID hypersensitivity .…”

Section: Hypersensitivity Induced By Non‐specific Immunological Mechamentioning

confidence: 99%

Advanced phenotyping in hypersensitivity drug reactions to NSAIDs

Ayuso¹,

Blanca‐López

Doña

et al. 2013

Clin Experimental Allergy

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Non-steroidal anti-inflammatory drugs (NSAIDs) are the medications most frequently involved in hypersensitivity drug reactions. Because NSAIDs are prescribed for many conditions, this is a world-wide problem affecting patients of all ages. Various hypersensitivity reactions have been reported, mainly affecting the skin and/or the respiratory airways. The most frequent of these is acute urticaria, which can be induced by several different NSAIDs. Both specific and non-specific immunological pathways have been proposed as underlying mechanisms. This review presents the clinical phenotypes and the drugs involved in NSAID hypersensitivity. Five major clinical syndromes can be distinguished: aspirin-exacerbated respiratory disease (AERD), aspirin-exacerbated cutaneous disease (AECD), multiple NSAID-induced urticaria/angioedema (MNSAID-UA), single NSAID-IgE reactions and single NSAID T cell responses. However, further classification is possible within these five major entities, by detailed descriptions of the clinical characteristics enabling more phenotypes to be defined. This detailed differentiation now seems required in order to undertake appropriate pharmacogenetic studies.

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Section: Hypersensitivity Induced By Non‐specific Immunological Mechamentioning

confidence: 99%