Nasal Irrigation for Upper Respiratory Conditions

Rabago, David; Hayer, Supriya; Zgierska, Aleksandra

doi:10.1016/b978-0-323-35868-2.00113-4

Cited by 32 publications

(43 citation statements)

References 33 publications

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“…When mucus debris is aspirated or rehydrated with a few drops of saline, it is seen that transport starts again (14). It has been emphasized in many studies that nasal irrigation is useful in seasonal allergic rhinitis, acute sinusitis, and chronic sinusitis (11,(15)(16)(17). In another study it was shown that using nasal saline and nasal corticosteroid together was more effective and economical than using nasal saline alone or nasal steroid alone (18).…”

Section: Discussionmentioning

confidence: 99%

Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection

Köksal¹,

Cizmeci²,

Bozkaya³

et al. 2016

Turk J Med Sci

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Section: Discussionmentioning

confidence: 99%

Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection

Köksal¹,

Cizmeci²,

Bozkaya³

et al. 2016

Turk J Med Sci

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“…This treatment could be effective for either those, who are hospitalized, or as prophylaxis treatment for nonhospitalized cases. It is worth to mention that this procedure is already used to improve lung function in cystic fibrosis patients 45 and nebulized 3% hypertonic saline treatment for infants with moderate to severe bronchiolitis is safe without adverse events such as bronchospasm, cough or wheezing aggravation [46][47][48] . However, this safe protocol has not, to our knowledge, been used to treat COVID-19 patients.…”

Section: Nacl Induces Cell Membrane Depolarization In a Dose-dependenmentioning

confidence: 99%

Hypertonic saline solution inhibits SARS-CoV-2 in vitro assay

Machado

Glaser

Araújo

et al. 2020

Preprint

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We are facing an unprecedented global health crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At this date more than 680 thousand people have died due to coronavirus disease 2019 (COVID-19). Unfortunately, until now no effective treatment to combat the virus and vaccine are available. We performed experiments to test if hypertonic saline solution is able to inhibit virus replication in vitro. Our data shows that 260 mM NaCl (1.5%) inhibits 100% SARS-CoV-2 replication in Vero cells. Furthermore, our results suggest that the virus replication inhibition is due to an intracellular mechanism and not due to the dissociation between spike SARS-CoV-2 protein and its human receptor angiotensin-converting enzyme 2 interaction. NaCl depolarizes the plasma membrane supposedly associated with the inhibition of the SARS-CoV-2 life cycle. This observation could lead to simple, safe and low cost interventions at various stages of COVID-19 treatment, improving the prognosis of infected patients, thereby mitigating the social and economic costs of the pandemic.

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“…Nasal irrigation is used as an additional therapy to treat various complaints of sinonasal because this therapy is inexpensive, simple, and effective. Nasal irrigation may improve nasal mucociliary function through a mechanism of nasal mucosa clearance from inflammatory mediators along with inhalant which is trapped in the nasal mucosa [10,11]. The solution that can be used for nasal irrigation is the solution isotonic, hypertonic, buffered and unbuffered.…”

Section: Introduction mentioning

confidence: 99%

“…The study shows that patients with chronic sinusitis symptoms who use saline irrigation 2% every day other than regular treatment have experienced improvement in their symptoms by 64% [11]. Hypertonic saline irrigation can accelerate mucociliary transport time of patients with chronic rhinosinusitis by 85%, while nasal irrigation by using isotonic saline increases mucociliary transport time by 31.19% [14].…”

Section: Introduction mentioning

confidence: 99%

Nasal Irrigation Effects towards Nasal Mucociliary Transport Time in Active Smokers

Cuddhi¹,

Marliyawati²,

D³

2020

JPP

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Nasal irrigation is often recommended as an adjuctive therapy for treating many sinonasal conditions. It provides mechanical cleansing of mucus, crust, cell debris and various air contaminants. The study was done to analyze the effect of nasal irrigation on change of nasal mucociliary transport time, in active smokers. This study was experimental using pre and post test controlled group design. Samples were divided into two groups; treatment and control group. The mucociliary transport time were tested with saccharin method for two times; before and fourteen days after treatment. On the day fourteen after nasal irrigation there was a significant decreased of the mucociliary transport time than before (p = 0,000). In the control group on second measurement was significantly longer compared to the first measurement (p = 0,003). In the comparison of mucociliary transport time change between treatment group and control group was found significant differences (p = 0,000).

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Nasal Irrigation for Upper Respiratory Conditions

Cited by 32 publications

References 33 publications

Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection

Comparison between the use of saline and seawater for nasal obstruction in children under 2 years of age with acute upper respiratory infection

Hypertonic saline solution inhibits SARS-CoV-2 in vitro assay

Nasal Irrigation Effects towards Nasal Mucociliary Transport Time in Active Smokers

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