2017
DOI: 10.18176/jiaci.0118
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Nasal Ketorolac Challenge Using Acoustic Rhinometry in Patients With Aspirin-Exacerbated Respiratory Disease

Abstract: Background: Safer and less time-consuming alternatives to single-blind placebo-controlled oral challenge (SBPCOC) have been sought for the diagnosis of aspirin-exacerbated respiratory disease (AERD). Nasal challenges with various nonsteroidal anti-inflammatory drugs and assessment methods have been developed. Objective: Our objective was to evaluate the utility and safety of nasal ketorolac challenge (NKC) using acoustic rhinometry in patients with suspected AERD. Methods: The study population comprised 36 pat… Show more

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Cited by 10 publications
(9 citation statements)
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“…Lysine-aspirin is not available in the USA, where nasal provocation is performed using intranasal ketorolac [33,91]. Experience with ketorolac has been reported by Quiralte-Castillo et al [92].…”
Section: Methodsmentioning
confidence: 99%
“…Lysine-aspirin is not available in the USA, where nasal provocation is performed using intranasal ketorolac [33,91]. Experience with ketorolac has been reported by Quiralte-Castillo et al [92].…”
Section: Methodsmentioning
confidence: 99%
“…Administration of drugs to the nose such as erythropoietin or glucagon did not cause serious adverse reactions [ 43 , 44 ]. Similarly, nasal ketorolac challenges in highly sensitized Samter’s triad patients rarely caused bronchospasm [ 45 ].…”
Section: Safety Potential Risks and Adverse Reactions To Nasal Nzace2-pātarimentioning
confidence: 99%
“…Brak jednoznacznego punktu odcięcia uzasadnia konieczność wykonania dodatkowo badań czynnościowych. [5]. Gdy zastosowano próg odcięcia 25% zmniejszenia objętości w rynometrii akustycznej, swoistość próby wynosiła 94%, a czułość 73%.…”
Section: Interpretacja Wynikuunclassified