Nasal mucociliary transport in laryngectomees

Abstract

A study has been carried out to assess the mucociliary function of nasal mucosa in 30 patients: 16 had undergone surgery due to larynx malignancy and the remaining 14 were divided in two groups. The first group was composed of seven patients suffering from larynx cancer but not operated, and the second group of seven had pathology not related to the airways (control group). The method used a 99mtechnetium sulphur colloid drop deposited on the nasal mucosa of one nostril. To calculate the rate of transport, a new method of quantification has been introduced, based on the formation of a parametric image. The mean velocity in laryngectomees was 3.6 mm/min (range 1.1-6.4). It was compared with the group of 14 patients without tracheostomy (mean 5.3, range 3.3-8.2). An impaired Student's-t-test gave a significant difference between both groups (P less than 0.005). The comparison between patients with nonoperated larynx cancer and normals gave a nonsignificant difference. The 16 operated patients were arbitrarily divided into two groups as per the time elapsed from laryngectomy; seven were studied within the first 3 years of operation and seven other patients after this term. The comparison between them was not significant.

Incidence of Sinunasal Disease in Laryngectomized Patients

“…Because of the absence of nasal airflow and thus the aspiration of irritating agents after laryngectomy, in some areas of the nasal cavity squamous epithelium is replaced by ciliated columnar epithelium [2,17] resulting in an acceleration of the mucociliary transport. As a result of reduced nasal ventilation, the mucociliary system atrophies and mucous production decreases [10,13,18] .…”