Nasal Mucosa in Pancreatic Cystic Fibrosis

Functional Endoscopic Sinus Surgery Improves Sinus-Related Symptoms and Quality of Life in Children With Chronic Rhinosinusitis

“…The association of cystic fibrosis with nasal polyps in children was first reported by Lurie, 34 but its importance has been reiterated by other authors. 35,36 Our meta-analysis showed that FESS in these children improves both their sinusitis symptoms and their quality of life, albeit for a more limited time period compared to otherwise healthy children (not exceeding 3 to 5 years according to Younis and Lazar 18 ). Despite the uniform nature of the aforementioned results, the quality of the related studies, and the lack of a specific suggestion about the clinical effectiveness of FESS in the only Level II study within this group of studies, allows us to adopt a grade C strength in the respective recommendations.…”

“…2,18 Unfortunately, the presence of these factors was not uniformly recorded in our study population. 35,36 Our meta-analysis showed that FESS in these children improves both their sinusitis symptoms and their quality of life, albeit for a more limited time period compared to otherwise healthy children (not exceeding 3 to 5 years according to Younis and Lazar 18 ). 18 It was therefore deemed important to assess the impact of FESS in cystic fibrosis children with nasal polyps in the present meta-analysis.…”

Avaliação endoscópica nasal de crianças e adolescentes com fibrose cística

“…From 1961 to 2005, the prevalence of nasal polyps increased from 5 to 57%. 26,29,[31][32][33][34][35][36][37][38][40][41][42] Explanations include increased survival rates of CF patients in developed countries, the selection of patients, sample sizes, different age groups in these studies, and especially the more recent routine use of nasal endoscopy as a diagnostic tool. 3,19,48 Brihaye et al 29 showed that over 25% of polyps were not diagnosed in the clinical examination with anterior rhinoscopy without nasal endoscopy in CF patients.…”

“…[28][29][30] The frequency of nasal polyposis varies in different populations, and depends on the evaluation technique. 26,29,[31][32][33][34][35][36][37][38][39][40][41][42] It is thought that nasosinusal involvement may worsen pulmonary manifestations; 20 thus, otorhinolaryngologists have become more involved in evaluating these patients. Recent studies in Brazil 26,40,41 have shown a growing concern with characterizing in more detail the nasosinusal findings of CF patients, because this disorder is genetically very heterogeneous, with many types of mutations and a wide variety of clinical presentations, 28 which may be explained by specific phenotypic features of the Brazilian population and even within populations of any given region in this country.…”

Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis.

“…Nasal mucociliary clearance was determined to obtain an in vivo measurement of the effectiveness of the interaction between cilia and mucus in these patients. Sinusitis is almost universal in patients with cystic fibrosis although often asymptomatic.7 8 Because of this, the measurements were made in normal subjects and in a group of patients with sinusitis but no chest disease. The intrathoracic pathology which develops in patients with cystic fibrosis usually includes the changes of bronchiectasis.9 A group of patients with bronchiectasis not caused by cystic fibrosis was therefore included in the study.…”