Nasal obstruction as a key symptom in allergic rhinitis: efficacy and safety of a medical device in children

Passàli, Desiderio; Bellussi, Luisa; Gregori, Darío; Lauriello, M; Passàli, Francesco Maria; Passàli, Giulio Cesare

doi:10.1016/j.otpol.2012.05.019

Cited by 7 publications

(8 citation statements)

References 15 publications

(20 reference statements)

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“…16 Both the anti-inflammatory and cleansing action seem to restore the "cytological architecture" of the nasal mucosa. 17,18 In a comparative study, Mansi et al observed a similar benefit of intranasal glycyrrhizin and mannitol and intranasal corticosteroid in reducing nasal congestion. 6 Nasal corticosteroids are currently the first therapeutic choice in chronic rhinopathies.…”

Section: Discussionmentioning

confidence: 95%

Glycyrrhizin and Mannitol Nasal Therapy: Cytological and Clinical Outcomes in Chronic Rhinitis

Pagliuca

Clemenzi

Martellucci

et al. 2023

Int Arch Otorhinolaryngol

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Introduction Chronic rhinitis (CR) represents a widespread inflammation with a high incidence in the general population. Although it is generally considered a benign condition, CR has a relevant impact on quality of life and requires a specific treatment approach. Objective The aim of the present study was to investigate the efficacy of glycyrrhizin and mannitol intranasal treatment on chronic rhinitis using cytological analysis and subjective evaluation of symptoms. Methods A total of 55 patients suffering from chronic rhinitis were enrolled in the present study, 34 with allergic rhinitis (AR) and 21 with nonallergic rhinitis (NAR). The severity of four different nasal symptoms was determined by using a visual analogue scale (VAS). Specimens obtained by nasal scraping were collected for cytological analysis. Data were acquired before and after a 30-day treatment with glycyrrhizin and mannitol nasal spray. Statistical analyses were performed. Results The VAS scores for all four nasal symptoms considered in the present study, as well as for neutrophil cells, reduced significantly after therapy in both allergic and nonallergic patients. The number of eosinophils was not significantly lower in nonallergic patients. Conclusion A 30-day topical treatment with glycyrrhizin and mannitol may improve nasal symptoms and reduce inflammatory cells in the nasal mucosa in patients with chronic rhinitis without significant contraindications. Further studies could support our results and would better clarify all the aspects of this treatment.

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Section: Discussionmentioning

confidence: 95%

Glycyrrhizin and Mannitol Nasal Therapy: Cytological and Clinical Outcomes in Chronic Rhinitis

Pagliuca

Clemenzi

Martellucci

et al. 2023

Int Arch Otorhinolaryngol

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“…Two studies by Passali et al investigated the effects of a nasal spray containing dexpanthenol for the treatment of allergic rhinitis in children for periods of 4 weeks and 2 weeks, respectively [ 36 , 37 ]. They studied 100 children in one trial and 50 children in the other trial.…”

Section: Discussionmentioning

confidence: 99%

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays

Mösges

Shah‐Hosseini

Hucke³

et al. 2017

Adv Ther

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Nasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, we could demonstrate that the benefit of added dexpanthenol appears as early as on the third day of the combined application of xylometazoline and dexpanthenol in terms of complete or near-to-complete freedom from symptoms. After 5 days, 47% of the patients were cured under the combined treatment compared with only 1% under xylometazoline monotherapy. These data show that the addition of dexpanthenol to an alpha-sympathomimetic nasal spray not only improves its tolerability but also further increases its effectiveness and leads to expedited cure.Funding: Klosterfrau Healthcare Group.

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“…This was achieved by tilting the T cell balance towards a Th1 phenotype out of the allergic Th2 and Th17 ones [ 131 ]. Studies on humans showed the efficacy of a multicomponent device containing LF in children, improving AR symptoms evaluated with a Visual Analogue scale and objectivated through Active Anterior Rhinomanometry and Mucociliary Transport Time [ 142 , 143 ]. The clinical application of LF may also be helpful in the diagnosis of AR; as mentioned previously, it has been proposed that LF might serve as an early detection biomarker, given that the combination of serum LF concentration and antigen-specific IgE levels can predict the condition with a suitable sensitivity and specificity [ 81 ].…”

Section: Lactoferrin Clinical Application In Allergic Airway Diseasesmentioning

confidence: 99%

“…The proposed actions of LF could benefit from a systemic approach, as this protein impacts a variety of metabolic and regulatory pathways, particularly meriting further examination in paediatric applications. Only the two reported studies evaluated the efficacy of LF administration in AR in children, but it is associated with other components [ 142 , 143 ]. Our manual research has found a patent application and a phase II clinical trial for its use in asthma.…”

Section: Lactoferrin Clinical Application In Allergic Airway Diseasesmentioning

confidence: 99%

Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough

Gori,

Brindisi,

Daglia

et al. 2024

Nutrients

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The prevalence of allergic diseases has dramatically increased among children in recent decades. These conditions significantly impact the quality of life of allergic children and their families. Lactoferrin, a multifunctional glycoprotein found in various biological fluids, is emerging as a promising immunomodulatory agent that can potentially alleviate allergic diseases in children. Lactoferrin’s multifaceted properties make it a compelling candidate for managing these conditions. Firstly, lactoferrin exhibits potent anti-inflammatory and antioxidant activities, which can mitigate the chronic inflammation characteristic of allergic diseases. Secondly, its iron-binding capabilities may help regulate the iron balance in allergic children, potentially influencing the severity of their symptoms. Lactoferrin also demonstrates antimicrobial properties, making it beneficial in preventing secondary infections often associated with respiratory allergies. Furthermore, its ability to modulate the immune response and regulate inflammatory pathways suggests its potential as an immune-balancing agent. This review of the current literature emphasises the need for further research to elucidate the precise roles of lactoferrin in allergic diseases. Harnessing the immunomodulatory potential of lactoferrin could provide a novel add-on approach to managing allergic diseases in children, offering hope for improved outcomes and an enhanced quality of life for paediatric patients and their families. As lactoferrin continues to capture the attention of researchers, its properties and diverse applications make it an intriguing subject of study with a rich history and a promising future.

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Nasal obstruction as a key symptom in allergic rhinitis: efficacy and safety of a medical device in children

Cited by 7 publications

References 15 publications

Glycyrrhizin and Mannitol Nasal Therapy: Cytological and Clinical Outcomes in Chronic Rhinitis

Glycyrrhizin and Mannitol Nasal Therapy: Cytological and Clinical Outcomes in Chronic Rhinitis

Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays

Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough

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