Nasal Polyps in Cystic Fibrosis

Henriksson, Gert; Westrin, Karl Magnus; Karpati, Ferenc; Wikström, Ann–Charlotte; Stierna, Pontus; Hjelte, Lena

doi:10.1378/chest.121.1.40

Cited by 75 publications

(23 citation statements)

References 47 publications

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“…Of these, in regards to the classification, two had bilateral level III polyposis, one had bilateral level II polyposis and three had unilateral of local infection/inflammation. In the population studied we observed an incidence of sinusitis and oral breathing in 22% of the patients, and such incidence rates are similar to the ones reported by other authors 9,10,13,19 ; however only one of these patients reported nasal polyps. Similar data were published in 2002 by Henriksson et al 13 in a study involving 111 patients with cystic fibrosis with median age of 18 years.…”

Section: Discussionsupporting

confidence: 91%

“…In the population studied we observed an incidence of sinusitis and oral breathing in 22% of the patients, and such incidence rates are similar to the ones reported by other authors 9,10,13,19 ; however only one of these patients reported nasal polyps. Similar data were published in 2002 by Henriksson et al 13 in a study involving 111 patients with cystic fibrosis with median age of 18 years. During nasal endoscopic exam they observed nasal polyps in 39% of the patients; however they found no correlation between nasal obstruction, nasal secretion and polyps in these patients.…”

Section: Discussionsupporting

confidence: 91%

“…Similar to the study carried out by Henriksson et al 13 , the polyps were classified as small in 68% of the patients; in 23% the polyps were in the meatus, being diagnosed only by means of nasal endoscopy. In our study, four (45%) patients had small polyps, stressing the importance of routine nasal endoscopy and clinician-otolaryngologist interaction.…”

Section: Discussionsupporting

confidence: 63%

“…Sinusal disease, diagnosed by CT scan, has been reported in CF in up to 100% of the cases 9,10,11,13,14 , although the percentage of adult patients with clinical manifestation is much lower 7,8,13 . It is believed that the thick mucus reduces ciliary movement, causes meatal obstruction and both hypercapnia and hypoxia facilitate the development After six months of clinical treatment with topical steroids in the habitual dose, we observed that of the nine children with polyps, seven (67.7%) improved.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations in the upper airways (UAW) happen to 100% of the patients, including recurrent sinusitis, rhinitis and/or nasal polyposis [8][9][10][11] . The incidence of nasal polyps has been reported in 6 to 48% of the cases 12,13 , by the time cystic fibrosis is diagnosed, about 4% of the patients have some symptoms associated with nasal polyps. It is believed that about 14% of the patients with cystic fibrosis will require surgery to treat the polyps 8,10,11,14 .…”

Section: Introductionmentioning

confidence: 99%

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Incidência e evolução da polipose nasal em crianças e adolescentes com fibrose cística

Weber¹,

Ferrari²

2008

Rev. Bras. Otorrinolaringol.

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Nasal polyps are a clinical sign of alert for investigatingCystic Fibrosis (CF). Aims: To study the incidence of nasal polyps in children and adolescents with cystic fibrosis, its possible association with age, gender, clinical manifestations, genotype and sweat chlorine level, and its evolution with topical steroid therapy. Methods: Clinical symptoms, sweat chlorine level and genotype were studied in 23 cystic fibrosis patients. Nasal polyps were diagnosed by nasal endoscopy and treated with topical steroids during 6 months, followed by a second nasal endoscopy. Fisher test was used for statistical analysis. Results: Nasal polyps were found in 39.1% of the patients (five bilateral, four unilateral), all older than six years, recurrent pneumonia in 82.6%, pancreatic insufficiency in 87% and malnutrition in 74%. No association was seen between nasal polyps and sweat chlorine level, genotype, clinical sings of severity and nasal symptoms. Seven patients improved in their nasal polyps with topical steroids, six showed complete resolution. Conclusion: The study showed a high incidence of nasal polyps in older children, who span the entire range of clinical severity, even in the absence of clinical nasal symptoms. Topical steroid therapy showed good results. An interaction among pediatricians and otolaryngologists is necessary for diagnosis and follow-up.

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