Nasal Reconstruction Using the Integra Dermal Regeneration Template

Abstract

Summary: The reconstruction of nasal defects following oncologic resection has traditionally involved the use of locoregional flaps or full-thickness skin grafts. However, these options are not always feasible because of limitations in donor tissues, defect size or shape, oncologic issues, or patient preference. Reconstruction in this setting has been limited and unsatisfactory. In this report, the authors present their experience in reconstruction of nasal defects using the dermal regeneration template Integra. In most cases, reconstruction with Integra enabled a single-stage, satisfactory reconstruction. The authors present a simple, standardized technique for application and postoperative care, which has resulted in good aesthetic outcomes. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.

Single-stage extremity reconstruction through the use of dermal matrices: the power of Integra® bilayer wound matrix in the face of medical comorbidities, patient preference and non-compliance

“…For patients for whom the single-stage procedure occurred due to patient non-compliance (patients 2 and 4), we reported significant re-epithelialization with new skin formation, despite the extreme non-compliance. All 4 patients did not develop contractures, as previously reported for single-stage re-epithelialization using IBWM [ 28 ]. In addition, we reported in one patient (patient 4), dermal appendages such as hair follicles had returned.…”

“…The most common reason for single-stage reconstruction with re-epithelialization was patient preference to avoid an autologous reconstruction, followed by large defect size/depth. Average time for complete re-epithelialization was 1.5 ± 0.8 months [ 28 ]. For patients for whom the single-stage procedure was conducted due to patient preference (patients 1 and 3), these patients were monitored closely during the re-epithelialization process, and followed medical advices and indications for wound management.…”

Technical Refinements with the Use of Biologic Healing Agents

“…47 Another case series assessing the use of Integra for nasal defects after oncological resection demonstrated that while Integra was effective as a treatment modality, postoperative complications including contour deformity (18.8%), hyperpigmentation (12.5%), and alar retraction (12.5%) were observed. 49…”

Reconstruction of Nasal Subunits using a Nasolabial Flap: Case Report

“…Various methods have been used in nasal reconstruction, ranging from dermal regeneration (integra) [6], skin grafts, as well as a wide variety of flaps; The nasolabial flap, frontal flap and the frontonasal flap are recognized as the main pillars in nasal reconstruction [7].…”