Nasal Saline Irrigation Facilitates Control of Allergic Rhinitis by Topical Steroid in Children

Li, Hua-Bin; Sha, Q.; Zuo, Kejun; Jiang, Hongyan; Cheng, Long; Shi, Jianbo; Xu, Geng

doi:10.1159/000178165

Cited by 61 publications

(54 citation statements)

References 49 publications

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“…The positive effect of nasal irrigation with hypertonic saline on the clinical course of seasonal Parietaria-related AR and the need for drug administration to control its signs and symptoms has been previously demonstrated in children by Garavello et al (11,12) and Li et al (13). However, our findings extend our knowledge of the impact of nasal irrigation in children with seasonal grass pollen-related AR.…”

Section: Discussionsupporting

confidence: 83%

“…We also found that a bulb syringe can be correctly used by adequately instructed school-aged children supervised by their parents. Finally, both the children and their parents easily accepted the relatively small volume of fluid instilled twice a day, thus overcoming the problem of the need to administer larger volumes reported by some authors (13).…”

Section: Discussionmentioning

confidence: 94%

“…The quantitative variables were compared using the Mann-Whitney test, Wilcoxon's signed rank sum test for paired data or Kruskal-Wallis test for between groups differences. Sample size was not calculated a priori because this type of calculation is determined by the rate of events in the control group, which could vary widely in case ofallergic rhinitis (11)(12)(13)(14), nevertheless we decided to enroll a sample much larger than that usually included in the previous pediatric studies. All of the tests were two sided and a P value of <0.05 was considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Hypertonic Saline is More Effective Than Normal Saline in Seasonal Allergic Rhinitis in Children

Marchisio

Varricchio

Baggi

et al. 2012

Int J Immunopathol Pharmacol

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Allergic rhinitis (AR) is a very common childhood disease that is associated with a significant reduction in the patients' quality of life. Its treatment combines educating the patients and their parents, immunotherapy and drug administration. However, even the best approach does not relieve the symptoms of a number of patients. Alternative therapies are particularly needed for children because the fear of adverse events frequently reduces parental compliance to the prescribed drugs, and immunotherapy is less easy to administer than in adults. In this prospective investigator-blinded study we evaluated whether children, with a documented history of seasonal grass pollen-related AR, benefit from nasal irrigation by assessing the effects on nasal signs and symptoms, on middle ear effusion and on adenoidal hypertrophy. We randomized children aged 5 to 9 years (median age 82 months) to normal saline or hypertonic saline (a 2.7% sodium chloride solution), administered twice-daily using a disposable 20 ml syringe, or no treatment. Nasal symptoms (rhinorrhea, itching, sneezing, nasal obstruction), swelling of turbinates, adenoid hypertrophy or middle ear effusion were assessed at baseline and after 4 weeks of treatment. Two hundred and twenty children (normal saline: 80; hypertonic saline: 80; no treatment: 60) completed the study. After four weeks, all the considered items were significantly reduced in the group receiving hypertonic saline (P <0.0001), whereas in the group receiving normal saline only rhinorrhea (P = 0.0002) and sneezing (P = 0.002) were significantly reduced. There was no significant change in any of the items in the control group. The duration of oral antihistamines was significantly lower in the children receiving hypertonic saline than in those treated with normal saline or in controls. No adverse events were reported and parental satisfaction and compliance with the procedure were globally very good, regardless of the solution used. Using our procedure, hypertonic saline is effective, inexpensive, safe, well tolerated and easily accepted by children with seasonal grass pollen-related AR and their parents. Our data suggest that nasal irrigation with hypertonic saline might be included in the wide spectrum of therapies recommended for grass-pollen AR.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hypertonic Saline is More Effective Than Normal Saline in Seasonal Allergic Rhinitis in Children

Marchisio

Varricchio

Baggi

et al. 2012

Int J Immunopathol Pharmacol

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“…Rinsing the nasal cavity with saline is an inexpensive method of treating rhinitis with low, but proven efficacy [23,24].…”

Section: Moisturizersmentioning

confidence: 99%

Modern Principles of Allergic Rhinitis Therapy in Children

Вишнёва¹,

Намазова-баранова²,

Алексеева³

et al. 2014

Pediatr. farmakol.

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Modern principles of allergic rhinitis therapy in childrenAllergic diseases, the prevalence rate of which continues to grow, constitute a global issue for the world healthcare. Allergic rhinitis (AR) is a disease widespread among the children and adolescents, causing extensive socio-economic load as well as negative influence on the quality of life of both the patients and the members of their families [1−5]. Moreover, according to the results of the epidemiological studies, 10-40% of AR patients also suffer from bronchial asthma (BA). At the same time, almost 100% of BA patients, at least among the children, complain of AR manifestations. Constant sneezing, itching, rhinorrhea, nasal obstruction, cough and snoring, sleep disorders and fatigue negatively influence physical and psychological condition and social wellbeing, causing downslide in school performance [6]. Despite the presence of excruciating symptoms, the proven interconnection with and the influence on bronchial asthma, the issue of AR is often paid very little attention to, sometimes no more than a usual cold [5]. As a result, most of the pediatric patients either do not receive any adequate therapy they require, or are treated sporadically, taking palliative medications, falling out of modern treatment regimens. One of the reasons of this situation, which is not exclusively typical for our country, is the absence of guidelines on allergic rhinitis in children and its differences from the rhinitis in adults. The acute problem of choosing the correct treatment aiming at controlling the AR

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“…It permitted use of less topical steroids for controlled AR in children which will contribute to fewer side effects and less economic burden [5].…”

Section: Filtrationmentioning

confidence: 99%

Looking after local nasal and sinus mucosa in health, disease and after surgery

Kacker¹

2010

Indian J Otolaryngol Head Neck Surg

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The paper emphasises the need for looking after of nasal and sinus mucosa in health, disease and after nasal surgery. It is a systematic arrangement of steps required to restore nasal mucosa to healthy state. These steps have been arranged to co relate them to diseases and symptoms for symptomatic and curative treatment. It can rationalise the need for surgery in cases non responsive to maximum medical treatment. It can improve postoperative surgical results after functional endoscopic sinus surgery (FESS) and other endoscopic assisted procedures.Keywords Nasal mucosa · Local medical management S. K. Kacker Delhi ENT Hospital and Research Centre, Jasola, New Delhi, India S. K. Kacker () E-mail: kacker.santosh@gmail.com Nasal mucosa plays a very important role as the guard of airway to lung. It has important function of ventilation, filtration and olfaction in addition it manufactures chemicals. The status of nasal mucosa can be affected by a number of nasal diseases -acute and chronic infections, environmental factors, stress and increasingly the iatrogenic, surgical interventions for surgery on nose, sinuses and as an approach to tumors of pituitary, anterior cranial fossa and clival area. Thus, the need to understand the steps that can improve the health of nasal mucosa and maintain it becomes very important. For purposes of presentation the function, complaints and management have be grouped separately. However, nose function as a whole (holistically). Local medical management of nasal mucosaThe local management of nasal diseases is basically to restore nasal functions. The drugs so given are absorbed in smaller quantities than oral and injectable drugs and are less likely to affect systemically. Thus, effect of steroids for example on blood glucose, blood pressure and gastric acidity can be reduced. The effect of decongestants on blood pressure is significantly less when given nasally. The growth in children is not effected by steroids given nasally as much as those given orally. Postoperatively the local management after nasal surgery significantly reduces discomfort and improves healing. The detailed steps in diseases to restore specific nasal function are discussed in Tables 1 and 2. Ventilatory functionIt allows inhalation and normal environment for delicate nasal mucosa. The oxygen tension of sinuses is raised. The air from nose can enter ear through Eustachian tube.

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Nasal Saline Irrigation Facilitates Control of Allergic Rhinitis by Topical Steroid in Children

Cited by 61 publications

References 49 publications

Hypertonic Saline is More Effective Than Normal Saline in Seasonal Allergic Rhinitis in Children

Hypertonic Saline is More Effective Than Normal Saline in Seasonal Allergic Rhinitis in Children

Modern Principles of Allergic Rhinitis Therapy in Children

Looking after local nasal and sinus mucosa in health, disease and after surgery

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